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本文引用的文献

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The Physics of Cellular Decision Making During Epithelial-Mesenchymal Transition.上皮-间质转化过程中细胞决策的物理学原理。
Annu Rev Biophys. 2020 May 6;49:1-18. doi: 10.1146/annurev-biophys-121219-081557. Epub 2020 Jan 8.
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Head and Neck Cancer.头颈癌
N Engl J Med. 2020 Jan 2;382(1):60-72. doi: 10.1056/NEJMra1715715.
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Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: The Past, the Present and the Future.细胞周期蛋白依赖性激酶4/6抑制剂在乳腺癌中的最新综述：过去、现在与未来
J Cancer. 2019 Oct 21;10(26):6608-6617. doi: 10.7150/jca.33079. eCollection 2019.
4
Targeting CMTM6 Suppresses Stem Cell-Like Properties and Enhances Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.靶向 CMTM6 抑制头颈部鳞状细胞癌中的干细胞样特性并增强抗肿瘤免疫。
Cancer Immunol Res. 2020 Feb;8(2):179-191. doi: 10.1158/2326-6066.CIR-19-0394. Epub 2019 Nov 26.
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Surg Oncol Clin N Am. 2020 Jan;29(1):127-144. doi: 10.1016/j.soc.2019.08.010.
6
Research Advances in CKLF-like MARVEL Transmembrane Domain-containing Family in Non-small Cell Lung Cancer.非小细胞肺癌中 CKLF 样 MARVEL 跨膜结构域家族的研究进展。
Int J Biol Sci. 2019 Sep 7;15(12):2576-2583. doi: 10.7150/ijbs.33733. eCollection 2019.
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A gene regulatory network to control EMT programs in development and disease.一个调控 EMT 程序的基因调控网络，可用于发育和疾病的调控。
Nat Commun. 2019 Nov 11;10(1):5115. doi: 10.1038/s41467-019-13091-8.
8
CMTM6, the newly identified PD-L1 regulator, correlates with PD-L1 expression in lung cancers.CMTM6是新发现的程序性死亡受体配体1（PD-L1）调节因子，与肺癌中的PD-L1表达相关。
Biochem Biophys Rep. 2019 Oct 3;20:100690. doi: 10.1016/j.bbrep.2019.100690. eCollection 2019 Dec.
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Induction chemotherapy in head and neck cancers: Results and controversies.头颈部癌症的诱导化疗：结果与争议。
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Therapeutic Co-targeting of WEE1 and ATM Downregulates PD-L1 Expression in Pancreatic Cancer.治疗性共靶向 WEE1 和 ATM 下调胰腺癌中的 PD-L1 表达。
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CMTM6通过与NRP1相互作用促进口腔鳞状细胞癌的细胞增殖和侵袭。

CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1.

作者信息

Zheng Yang, Wang Chundi, Song An, Jiang Feng, Zhou Junbo, Li Gang, Zhang Wei, Ye Jinhai, Ding Xu, Zhang Wei, Du Yifei, Zhang Hongchuang, Wu Heming, Song Xiaomeng, Wu Yunong

机构信息

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University Nanjing, China.

Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomotology, Nanjing Medical University Nanjing, China.

出版信息

Am J Cancer Res. 2020 Jun 1;10(6):1691-1709. eCollection 2020.

PMID:32642284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7339282/
Abstract

Previous studies have identified that both CKLF-like MARVEL transmembrane domain-containing member (CMTM6) and Neuropilin-1 (NRP1) played an essential part in regulating tumorigenesis and immune response. However, the potential connection between CMTM6 and NRP1 in oral squamous cell carcinoma (OSCC) remains unknown. In this study, we investigated the clinicopathologic significance of CMTM6 and NRP1 in OSCC. We examined the co-expression of CMTM6 and NRP1 in both OSCC tissues and cell lines. Co-overexpression of CMTM6 and NRP1 was generally highly expressed in cancer tissues and is associated with poor prognosis. Gain- and loss-of-function assays confirmed the oncogenic properties of CMTM6 in OSCC cells. Depletion of NRP1 abrogated tumorigenesis induced by CMTM6. By performing co-immunoprecipitation (co-IP), we discovered a potential interaction between CMTM6 and NRP1. Meanwhile, the stability of CMTM6 was significantly decreased in the NRP1-silencing cells, indicating the involvement of NRP1 in the degradation process of CMTM6. The crosstalk between CMTM6 and NRP1 provided a new insight into the progression of OSCC, which may indicate an alternative strategy for OSCC treatment.

摘要

先前的研究已经确定，含CKLF样MARVEL跨膜结构域成员（CMTM6）和神经纤毛蛋白-1（NRP1）在调节肿瘤发生和免疫反应中都起着至关重要的作用。然而，CMTM6与NRP1在口腔鳞状细胞癌（OSCC）中的潜在联系仍不清楚。在本研究中，我们调查了CMTM6和NRP1在OSCC中的临床病理意义。我们检测了CMTM6和NRP1在OSCC组织和细胞系中的共表达情况。CMTM6和NRP1的共过表达在癌组织中通常高度表达，且与预后不良相关。功能获得和功能丧失实验证实了CMTM6在OSCC细胞中的致癌特性。NRP1的缺失消除了CMTM6诱导的肿瘤发生。通过进行免疫共沉淀（co-IP），我们发现CMTM6和NRP1之间存在潜在的相互作用。同时，在NRP1沉默的细胞中，CMTM6的稳定性显著降低，表明NRP1参与了CMTM6的降解过程。CMTM6和NRP1之间的相互作用为OSCC的进展提供了新的见解，这可能为OSCC治疗指明了一种替代策略。