非小细胞肺癌中 CKLF 样 MARVEL 跨膜结构域家族的研究进展。

China Medical University-The Queen's University of Belfast Joint College, Shenyang, Liaoning, 110122, China.

Institute of Translational Medicine, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, 110122, China.

Int J Biol Sci. 2019 Sep 7;15(12):2576-2583. doi: 10.7150/ijbs.33733. eCollection 2019.

CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an important role in the hematopoiesis system, the immune system, the cardiovascular system and the male reproductive system. Recent in-depth research has also revealed that CMTM is closely associated with the genesis, development and metastasis of tumors, displaying opposing activities in diverse human tumors. In this review, we discuss the structural and functional characteristics of the CMTM family and summarize latest research findings of the relationship between several CMTM members and non-small cell lung cancer.

CKLF 样 MARVEL 跨膜结构域包含成员（CMTM）是 2001 年首次克隆和报道的新基因家族。CMTM 家族由九个成员组成，包括 CKLF 和 CMTM1-CMTM8，它们位于不同的染色体上。除了表现出广泛的趋化活性外，CMTM 家族在造血系统、免疫系统、心血管系统和男性生殖系统中也发挥着重要作用。最近的深入研究还表明，CMTM 与肿瘤的发生、发展和转移密切相关，在不同的人类肿瘤中表现出相反的活性。在本文中，我们讨论了 CMTM 家族的结构和功能特征，并总结了几个 CMTM 成员与非小细胞肺癌之间关系的最新研究结果。