Guo Qin, Jiang Chen
Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Acta Pharm Sin B. 2020 Jun;10(6):979-986. doi: 10.1016/j.apsb.2020.01.009. Epub 2020 Jan 26.
With the development of biotherapy, biomacromolecular drugs have gained tremendous attention recently, especially in drug development field due to the sophisticated functions . Over the past few years, a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability, ., the instability and easily restricted by physiologic barriers. The application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life, increase the bioavailability, or improve patient compliance, which greatly improves the efficacy and potentiality for clinical use of biomacromolecular drugs. In this review, recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized, mainly drawing on the development over the last five years.
随着生物疗法的发展，生物大分子药物近来受到了极大关注，尤其是在药物开发领域，因其功能复杂。在过去几年中，已开发出各种各样的药物递送策略用于生物大分子药物，以克服成药方面的困难，即不稳定性以及易受生理屏障限制等问题。应用新型递送系统来递送生物大分子药物通常可以延长半衰期、提高生物利用度或改善患者顺应性，这极大地提高了生物大分子药物临床应用的疗效和潜力。在本综述中，总结了近期关于癌症治疗中大分子药物递送策略的研究，主要借鉴了过去五年的进展。
