长链非编码 RNA 在肿瘤血管生成中的调控作用及治疗应用。

Medical Research Center, Binzhou Medical University Hospital, Binzhou, P.R. China.

Department of Gynecology, Binzhou Medical University Hospital, Binzhou, P.R. China.

Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241273239. doi: 10.1177/15330338241273239.

Tumor growth and metastasis rely on angiogenesis. In recent years, long non-coding RNAs have been shown to play an important role in regulating tumor angiogenesis. Here, we review the multidimensional modes and relevant molecular mechanisms of long non-coding RNAs in regulating tumor angiogenesis. In addition, we summarize new strategies for tumor anti-angiogenesis therapies by targeting long non-coding RNAs. The aim of this study is to provide new diagnostic targets and treatment strategies for anti-angiogenic tumor therapy.

肿瘤的生长和转移依赖于血管生成。近年来，长非编码 RNA 被证明在调节肿瘤血管生成中发挥重要作用。在这里，我们综述了长非编码 RNA 调节肿瘤血管生成的多维模式和相关分子机制。此外，我们总结了通过靶向长非编码 RNA 进行肿瘤抗血管生成治疗的新策略。本研究旨在为抗血管生成肿瘤治疗提供新的诊断靶点和治疗策略。