Corbeel L, Eggermont E, Desmyter J, Surmont I, De Vos R, De Wolf-Peeters C, Cobbaert C, Eykens A
Department of Paediatrics, University of Leuven, Belgium.
Eur J Pediatr. 1988 Oct;148(1):32-3. doi: 10.1007/BF00441809.
A 3-month-old male infant presented with pallor, hepatomegaly (4.5 cm), splenomegaly (1.5 cm), anaemia (Hb 6 g/dl) and thrombocytopenia (16 X 10(9)/l). A liver biopsy was diagnostic for Langerhans cell histiocytosis (histiocytosis X). The patient's lymphocytes, co-cultured with neonatal lymphocytes, were positive for virus-like particles without reverse transcriptase activity. The hepatomegaly diminished after 6 months and a second liver biopsy showed decreased histiocytic infiltration. A second viral blood culture remained negative. After 14 months, the hepatomegaly had disappeared completely and there were no more abnormal haematological or clinical findings.
一名3个月大的男婴出现面色苍白、肝肿大（4.5厘米）、脾肿大（1.5厘米）、贫血（血红蛋白6克/分升）和血小板减少（16×10⁹/升）。肝脏活检诊断为朗格汉斯细胞组织细胞增多症（组织细胞增多症X）。该患者的淋巴细胞与新生儿淋巴细胞共培养时，对无逆转录酶活性的病毒样颗粒呈阳性。6个月后肝肿大减轻，第二次肝脏活检显示组织细胞浸润减少。第二次病毒血培养仍为阴性。14个月后，肝肿大已完全消失，血液学或临床检查不再有异常发现。
