共济失调毛细血管扩张症T细胞克隆的分子特征。III. 绘制14q32.1远端断点图谱。
Molecular characterization of ataxia telangiectasia T cell clones. III. Mapping the 14q32.1 distal breakpoint.
作者信息
Stern M H, Zhang F R, Thomas G, Griscelli C, Aurias A
机构信息
INSERM U. 132, Hôpital Necker, Paris, France.
出版信息
Hum Genet. 1988 Dec;81(1):18-22. doi: 10.1007/BF00283722.
PMID:3264259
Abstract
To delimit the 14q32.1 recurrent breakpoint of ataxia telangiectasia clones, we performed an in situ hybridization study with various probes located on the 14q32 band. We thus mapped this breakpoint between the D14S1 and Pi loci. Furthermore, an interstitial duplication including D14S1 and a part of the IgH locus was demonstrated on a t(14;14) clone.
摘要
为了界定共济失调毛细血管扩张症克隆中14q32.1的反复断裂点，我们使用位于14q32带的各种探针进行了原位杂交研究。因此，我们将该断裂点定位在D14S1和Pi基因座之间。此外，在一个t(14;14)克隆上发现了一个包括D14S1和一部分IgH基因座的间质性重复。
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