Xiao G X, Chopra R K, Adler W H, Munster A, Winchurch R A
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
J Trauma. 1988 Dec;28(12):1669-72. doi: 10.1097/00005373-198812000-00010.
Impairment of T-cell function is a consistent observation in burned patients. Concomitant with this impairment is an increase in serum factors which inhibit interleukin-2-mediated T-cell functions. These factors are heat labile and do not behave like endotoxins. Nonetheless, treatment of burned patients with endotoxin-neutralizing regimens of polymyxin B reduces the levels of these factors, suggesting that they are generated in response to endotoxin exposure. In addition to factors which inhibit Il-2 responses burn serum contains increases of circulating soluble, cell-free Il-2 receptors. However, the level of Il-2R is not altered by polymyxin B treatment and does not appear to be a direct result of endotoxin exposure. These observations suggest that multiple causes contribute to T-cell impairment in burned patients.
T细胞功能受损是烧伤患者中一直存在的现象。与此损伤相伴的是血清中抑制白细胞介素-2介导的T细胞功能的因子增加。这些因子对热不稳定，且行为不像内毒素。尽管如此，用多粘菌素B的内毒素中和方案治疗烧伤患者可降低这些因子的水平，表明它们是对内毒素暴露的反应而产生的。除了抑制白细胞介素-2反应的因子外，烧伤患者血清中循环可溶性无细胞白细胞介素-2受体也增加。然而，多粘菌素B治疗并不会改变白细胞介素-2受体的水平，且似乎不是内毒素暴露的直接结果。这些观察结果表明，多种原因导致了烧伤患者的T细胞损伤。
