Genetic polymorphisms in and were associated with dental caries and gingivitis.

OBJECTIVE

Evaluate the association between single nucleotide polymorphisms (SNPs) in () gene (rs1800795) and in () gene (rs1143627 and rs1143629) with dental caries and gingivitis in Brazilian children.

MATERIAL AND METHODS

Three hundred and fifty-three children aged 8-11 years were included. Visible biofilm and gingival bleeding were evaluated by Community Periodontal Index. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used to investigate dental caries. Real-time PCR evaluated SNPs in the DNA. Chi-square test, haplotype analysis and logistic regression were applied (alpha of 5%).

RESULTS

The GG genotype in rs1800795 () decreases the risk of gingivitis in a co-dominant model ( = .05; OR = 0.64). The GG genotype in rs1143627 () reduces the risk of dental caries (Co-dominant model: ICDAS versus ICDAS:  = .05; OR = 0.55. ICDAS versus ICDAS:  = .02; OR = 0.49. Recessive model: ICDAS versus ICDAS:  = .005; OR = 0.48. ICDAS versus ICDAS:  = .004; OR = 0.45. Logistic regression: ICDAS versus ICDAS:  = .05; OR = 0.24; CI 95%= 0.05-1.00). The GG genotype in rs1143629 was more frequent in ICDAS ( = .05; OR: 0.60). In the haplotype analysis, was associated with gingivitis.

CONCLUSION

The rs1800795 in gene was associated with gingivitis. The rs1143627 and rs1143629 in were associated with dental caries and gingivitis.