Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.
Dipartimento di Chimica, Università di Torino, Torino, Italy.
Clin Toxicol (Phila). 2021 Mar;59(3):185-192. doi: 10.1080/15563650.2020.1785488. Epub 2020 Jul 9.
Electronic dance music (EDM) party attendees are at high risk for drug use. However, little is known regarding the extent of underreporting of drug use in this population, in part, because use of synthetic drugs is often associated with unknown exposure to adulterant drugs. We estimated the extent of underreported drug use in this population by comparing self-reported use to hair toxicology results.
Time-space sampling was used to survey adults entering EDM events at nightclubs and dance festivals in New York City from January through August of 2019. Seven hundred ninety-four adults were surveyed and 141 provided analyzable hair samples. We queried past-year use of >90 drugs and tested hair samples using ultra-high performance liquid chromatography-tandem mass spectrometry. We compared hair test results to past-year self-reported use and adjusted prevalence estimates by defining use as reporting use or testing positive. Correlates of discordant reporting, defined as testing positive after not reporting use, were estimated.
Prevalence of drug use increased when considering positive hair tests in estimates, with 43.8% of participants testing positive for at least one drug after not reporting use. For example, based on self-report, cocaine use prevalence was 51.1%, and increased by a factor of 1.6 to a prevalence of 80.0% when adding hair test results to self-report. Younger adults (ages 18-25), black and other/mixed race participants, those reporting "other" sexuality, and those with a college degree were at significantly higher risk for testing positive for drugs not reportedly used. Those who self-reported using more types of drugs were less likely to test positive after not reporting use (adjusted prevalence ratio = 0.53, 95% confidence interval = 0.41-0.68).
We detected underreporting of drug use, particularly cocaine and ketamine. More research is needed to determine whether this is driven by intentional underreporting or unknown exposure through adulterants.
电子舞曲(EDM)派对参与者有较高的药物使用风险。然而,由于合成药物的使用通常与未知的掺杂物药物暴露有关,因此,关于该人群中药物使用报告不足的程度知之甚少。我们通过将自我报告的使用情况与头发毒理学结果进行比较,来估计该人群中药物使用报告不足的程度。
我们采用时空抽样方法,于 2019 年 1 月至 8 月期间,在纽约市的夜总会和舞蹈节上调查进入 EDM 活动的成年人。共调查了 794 名成年人,其中 141 名提供了可分析的头发样本。我们调查了过去一年中使用的 90 多种药物,并使用超高效液相色谱-串联质谱法对头发样本进行了测试。我们将头发测试结果与过去一年的自我报告使用情况进行了比较,并通过将使用定义为报告使用或检测阳性来调整流行率估计值。我们估计了定义为报告未使用但检测阳性的不一致报告的相关因素。
考虑到未报告使用但头发检测阳性的情况,药物使用的流行率增加,43.8%的参与者在未报告使用的情况下,至少有一项药物检测呈阳性。例如,根据自我报告,可卡因的使用流行率为 51.1%,当将头发测试结果添加到自我报告中时,可卡因的流行率增加了 1.6 倍,达到 80.0%。年轻成年人(18-25 岁)、黑人和其他/混合种族的参与者、报告“其他”性取向的参与者以及具有大学学历的参与者,检测到未报告使用的药物呈阳性的风险显著增加。那些自我报告使用的药物种类更多的人,在未报告使用的情况下,检测呈阳性的可能性较小(调整后的流行率比为 0.53,95%置信区间为 0.41-0.68)。
我们发现药物使用报告不足,尤其是可卡因和氯胺酮。需要进一步研究确定这是由于有意隐瞒还是由于掺杂物的未知暴露所致。