Department of Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.
J Med Virol. 2021 Jan;93(1):506-512. doi: 10.1002/jmv.26280. Epub 2020 Jul 15.
To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding. The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5°C), and time from onset to hospitalization were associated with prolonged duration of viral shedding (P < .05). Multivariate regression analysis showed that fever (temperature>38.5°C) (OR, 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR, 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR, 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding. Corticosteroid treatment, fever (temperature>38.5°C), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients.
探讨与 2019 冠状病毒病（COVID-19）患者严重急性呼吸综合征冠状病毒 2 型 RNA 脱落持续时间相关的因素。分析了北京一家指定医院收治的 COVID-19 患者的回顾性队列，以研究影响病毒脱落持续时间的因素。从发病开始测量，病毒脱落的中位持续时间为 11 天（IQR，8-14.3 天）。单因素回归分析显示，疾病严重程度、皮质类固醇治疗、发热（体温>38.5°C）和发病至住院时间与病毒脱落持续时间延长有关（P<.05）。多因素回归分析显示，发热（体温>38.5°C）（OR，5.1，95%CI：1.5-18.1）、皮质类固醇治疗（OR，6.3，95%CI：1.5-27.8）和发病至住院时间（OR，1.8，95%CI：1.19-2.7）与病毒脱落持续时间延长的几率增加相关。皮质类固醇治疗、发热（体温>38.5°C）和发病至住院时间延长与 COVID-19 患者的病毒延长脱落有关。
