血铅与血压：来自加拿大的横断面和纵向数据分析
Blood lead and blood pressure: analysis of cross-sectional and longitudinal data from Canada.
作者信息
Neri L C, Hewitt D, Orser B
机构信息
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario.
出版信息
Environ Health Perspect. 1988 Jun;78:123-6. doi: 10.1289/ehp.8878123.
Analysis of data collected during the Canada Health Survey of 1978-1979 indicated a positive relationship between blood lead and blood pressure, but so weak that the range of lead-related variation among members of the general public was estimated to be at most 3.0 mm Hg of diastolic pressure. Even so, a blood lead level in excess of the median value of 10 micrograms/dL entailed a 37% higher risk of having diastolic pressure above 90 mm Hg. In a longitudinal study of lead foundry workers, an association was found between short-term changes in an individual's blood lead level and contemporary changes in diastolic pressure; this remained significant after allowance for age (or time) trends and for effects attributable to changes in body weight. Short-term changes in urinary cadmium levels were similarly predictive of diastolic pressure.
对1978 - 1979年加拿大健康调查期间收集的数据进行分析表明，血铅与血压之间存在正相关关系，但这种关系很微弱，据估计，普通公众中与铅相关的血压变化范围最多为舒张压3.0毫米汞柱。即便如此，血铅水平超过10微克/分升的中位数会使舒张压高于90毫米汞柱的风险增加37%。在一项对铅铸造工人的纵向研究中，发现个体血铅水平的短期变化与舒张压的同期变化之间存在关联；在考虑年龄（或时间）趋势以及体重变化所产生的影响之后，这种关联仍然显著。尿镉水平的短期变化同样可预测舒张压。
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