Parkinson D K, Hodgson M J, Bromet E J, Dew M A, Connell M M
Department of Medicine, University of Pittsburgh, Pennsylvania.
Br J Ind Med. 1987 Nov;44(11):744-8. doi: 10.1136/oem.44.11.744.
Recent community studies have suggested that low level lead exposure is significantly associated with blood pressure in the general population. This finding is inconsistent with the results of recent occupational studies of lead exposed workers, although the occupational studies contained serious methodological weaknesses. The present study examined the relation between occupational lead exposure and diastolic and systolic blood pressure in randomly selected samples of 270 exposed and 158 non-exposed workers. Four exposure indicators were examined: employment at a lead battery plant nu a control plant, current blood lead value, current zinc protoporphyrin value, and time weighted average blood lead value. After controlling for other known risk factors such as age, education, income, cigarette usage, alcohol consumption, and exercise, the associations between exposure and blood pressure were small and non-significant. In the absence of a biologically feasible hypothesis regarding the mechanism by which low level lead exposure would influence blood pressure the present findings challenge the validity of the general population association.
近期的社区研究表明，一般人群中低水平铅暴露与血压显著相关。这一发现与近期针对铅暴露工人的职业研究结果不一致，尽管这些职业研究存在严重的方法学缺陷。本研究在随机抽取的270名暴露工人和158名未暴露工人样本中，考察了职业性铅暴露与舒张压和收缩压之间的关系。研究了四个暴露指标：在铅酸电池厂或对照厂工作、当前血铅值、当前锌原卟啉值以及时间加权平均血铅值。在控制了年龄、教育程度、收入、吸烟、饮酒和运动等其他已知风险因素后，暴露与血压之间的关联较小且无统计学意义。由于缺乏关于低水平铅暴露影响血压机制的生物学上可行的假说，目前的研究结果对一般人群中该关联的有效性提出了质疑。
