Department of Biology, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.
Department of Biomedical Sciences, University of Padua, Via U. Bassi 58/B, 35121 Padua, Italy.
Cells. 2020 Jul 7;9(7):1637. doi: 10.3390/cells9071637.
Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria-ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies.
线粒体和内质网（ER）之间的接触位点是两个细胞器紧密相邻的地方。由于它们结构和功能的复杂性，迄今为止，尚未将其作为药物靶点进行开发。尽管如此，描述直接或间接靶向这些界面上的蛋白质的化合物数量正在增加。在这里，我们提供了对线粒体-内质网接触位点（MERCs）的深入了解，并全面概述了当前的 MERCs 药理学。重要的是，我们讨论了 MERCs 成为开发新型治疗策略的可药用靶标的巨大潜力。
