Ahnood Arman, Meffin Hamish, Garrett David J, Fox Kate, Ganesan Kumaravelu, Stacey Alastair, Apollo Nicholas V, Wong Yan T, Lichter Samantha G, Kentler William, Kavehei Omid, Greferath Ursula, Vessey Kirstan A, Ibbotson Michael R, Fletcher Erica L, Burkitt Anthony N, Prawer Steven
School of Physics, University of Melbourne, Victoria, 3010, Australia.
National Vision Research Institute, Australian College of Optometry, Victoria, 3053, Australia.
Adv Biosyst. 2017 Feb;1(1-2):e1600003. doi: 10.1002/adbi.201600003. Epub 2016 Dec 5.
Retinal implants restore a sense of vision, for a growing number of users worldwide. Nevertheless, visual acuities provided by the current generation of devices are low. The quantity of information transferable to the retina using existing implant technologies is limited, far below receptor cells' capabilities. Many agree that increasing the information density deliverable by a retinal prosthesis requires devices with stimulation electrodes that are both dense and numerous. This work describes a new generation of retinal prostheses capable of upscaling the information density conveyable to the retina. Centered on engineered diamond materials, the implant is very well tolerated and long-term stable in the eye's unique physiological environment and capable of delivering highly versatile stimulation waveforms - both key attributes in providing useful vision. Delivery of high-density information, close to the retina with the flexibility to alter stimulation parameters in situ provides the best chance for success in providing high acuity prosthetic vision.
对于全球越来越多的用户来说，视网膜植入物恢复了视觉。然而，当前一代设备提供的视力较低。使用现有植入技术可传输到视网膜的信息量有限，远低于受体细胞的能力。许多人认为，提高视网膜假体可传递的信息密度需要具有密集且数量众多的刺激电极的设备。这项工作描述了新一代能够提高可传达至视网膜的信息密度的视网膜假体。该植入物以工程钻石材料为中心，在眼睛独特的生理环境中耐受性良好且长期稳定，并且能够提供高度通用的刺激波形——这是提供有用视力的两个关键属性。在靠近视网膜的位置传递高密度信息，并具备原位改变刺激参数的灵活性，为成功提供高敏锐度的假体视力提供了最佳机会。
