Department of Chemistry & Biochemistry, University of California San Diego, 9500, Gilman Drive, La Jolla, CA, 92093, USA.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500, Gilman Drive, La Jolla, CA, 92093, USA.
Curr Top Med Chem. 2022;22(15):1219-1234. doi: 10.2174/1568026622666220511154228.
Unlike the oxetane ring, which, as evidenced by numerous studies, is known to play an increasingly important role in medicinal chemistry, the thietane ring has thus far received comparatively limited attention. Nonetheless, a growing number of reports now indicate that this 4- membered ring heterocycle may provide opportunities in analog design. In the present review article, we discuss the possible use and utility of the thietane fragment in medicinal chemistry and provide an overview of its properties and recent applications with a focus on isosteric replacements.
与氧杂环丁烷不同，尽管有大量研究表明它在药物化学中发挥着越来越重要的作用，但硫杂环丁烷迄今为止受到的关注相对较少。尽管如此，越来越多的报道表明，这种 4 元杂环可能为类似物设计提供机会。在本文综述中，我们讨论了硫杂环丁烷片段在药物化学中的可能用途和实用性，并概述了其性质和最近的应用，重点介绍了等排替换。
