慢性化脓性鼻窦炎患者单核细胞趋化异常：血清中逆转录病毒p15E相关因子的作用。
Abnormal monocyte chemotaxis in patients with chronic purulent rhinosinusitis: an effect of retroviral p15E-related factors in serum.
作者信息
van de Plassche-Boers E M, Tas M, de Haan-Meulman M, Kleingeld M, Drexhage H A
机构信息
Laboratory for Clinical Immunology, Pathological Institute, Free University, Amsterdam, The Netherlands.
出版信息
Clin Exp Immunol. 1988 Sep;73(3):348-54.
Abstract
Earlier we reported that about 60% of patients suffering from unexplained relapsing of chronic purulent rhinosinusitis show a defective T cell-mediated immunity to commensal microorganisms of the upper respiratory tract. The monocyte chemotactic responsiveness was assessed in 40 of these patients by means of the polarization assay. Impaired FMLP-induced monocyte polarization was found in 26 of the 40 patients tested. The defective chemotactic responsiveness could be explained by a p15E-related factor detectable in the serum of the patients: addition of serum fractions less than 25 kD to healthy donor monocytes resulted in an inhibition of polarization; a monoclonal antibody directed against p15E neutralized this inhibitory effect. In individual patients, a decreased monocyte polarization correlated well with the presence of this p15E-related factor in serum, as well as with defective T cell reactivity.
摘要
我们之前报道过，约60%患有慢性化脓性鼻窦炎不明原因复发的患者，对呼吸道共生微生物表现出T细胞介导的免疫缺陷。通过趋化分析对其中40例患者的单核细胞趋化反应性进行了评估。在40例接受检测的患者中，有26例发现甲酰甲硫氨酸-亮氨酸-苯丙氨酸（FMLP）诱导的单核细胞趋化受损。趋化反应性缺陷可以用患者血清中可检测到的一种与p15E相关的因子来解释：将小于25kD的血清组分添加到健康供体单核细胞中会导致趋化抑制；针对p15E的单克隆抗体可中和这种抑制作用。在个体患者中，单核细胞趋化降低与血清中这种与p15E相关的因子的存在以及T细胞反应性缺陷密切相关。
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