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Absence of JAK2V617F Mutated Endothelial Colony-Forming Cells in Patients With JAK2V617F Myeloproliferative Neoplasms and Splanchnic Vein Thrombosis.

作者信息

Guy Alexandre, Danaee Anicee, Paschalaki Koralia, Boureau Lisa, Rivière Etienne, Etienne Gabriel, Mansier Olivier, Laffan Michael, Sekhar Mallika, James Chloe

机构信息

University of Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, F-33600 Pessac, France.

CHU de Bordeaux, Laboratoire d'Hématologie, F-33600 Pessac, France.

出版信息

Hemasphere. 2020 May 5;4(3):e364. doi: 10.1097/HS9.0000000000000364. eCollection 2020 Jun.

DOI:10.1097/HS9.0000000000000364
PMID:32647794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7306304/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe85/7306304/238d8d949433/hs9-4-e364-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe85/7306304/238d8d949433/hs9-4-e364-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe85/7306304/238d8d949433/hs9-4-e364-g002.jpg

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Front Med (Lausanne). 2018 Oct 23;5:295. doi: 10.3389/fmed.2018.00295. eCollection 2018.
2
Vascular endothelial cell expression of JAK2 is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.血管内皮细胞 JAK2 的表达足以通过增加 P-选择素的表达来促进促血栓形成状态。
Haematologica. 2019 Jan;104(1):70-81. doi: 10.3324/haematol.2018.195321. Epub 2018 Aug 31.
3
Endothelial Progenitors: A Consensus Statement on Nomenclature.
JAK-STAT 抑制可减少内皮细胞促血栓形成激活和白细胞-内皮细胞的促黏附相互作用。
J Thromb Haemost. 2023 May;21(5):1366-1380. doi: 10.1016/j.jtha.2023.01.027. Epub 2023 Feb 2.
4
Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms: Treatment Considerations and Unmet Needs.骨髓增殖性肿瘤中的内脏静脉血栓形成:治疗考量与未满足的需求
Cancers (Basel). 2022 Dec 20;15(1):11. doi: 10.3390/cancers15010011.
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