Focht J, Klietmann W, Nösner K, Rolinson G N, Johnsen J
Institut für Laboratoriumsmedizin, Moers, FRG.
Chemotherapy. 1988;34(4):332-40. doi: 10.1159/000238588.
17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80% of Gram-negative, 98% of Gram-positive and 97% of anaerobic isolates were susceptible to Augmentin (breakpoint 4 mg/l amoxicillin in the presence of 2.5 mg/l clavulanic acid). In a second part of the study the susceptibility to Augmentin of 4.137 Gram-negative and 10.958 Gram-positive pathogens was compared to their sensitivity against benzylpenicillin, flucloxacillin, mezlocillin, erythromycin, clindamycin, fusidic acid, ampicillin, cefaclor and doxycyclin.
对从德国北莱茵-威斯特法伦州默尔斯地区24家医院的临床标本中分离出的17244种病原体进行了阿莫西林克拉维酸（安灭菌）敏感性测试。为此，采用微量肉汤稀释技术测定了最低抑菌浓度。80%的革兰氏阴性菌、98%的革兰氏阳性菌和97%的厌氧菌对阿莫西林克拉维酸敏感（在含有2.5mg/l克拉维酸的情况下，阿莫西林的断点浓度为4mg/l）。在该研究的第二部分，将4137种革兰氏阴性菌和10958种革兰氏阳性菌病原体对阿莫西林克拉维酸的敏感性与其对苄青霉素、氟氯西林、美洛西林、红霉素、克林霉素、夫西地酸、氨苄西林、头孢克洛和强力霉素的敏感性进行了比较。
