• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

540株厌氧革兰氏阴性杆菌对阿莫西林、阿莫西林 - BRL 42715、阿莫西林 - 克拉维酸、替马沙星和克林霉素的敏感性。

Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin.

作者信息

Appelbaum P C, Spangler S K, Shiman R, Jacobs M R

机构信息

Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033.

出版信息

Antimicrob Agents Chemother. 1992 May;36(5):1140-3. doi: 10.1128/AAC.36.5.1140.

DOI:10.1128/AAC.36.5.1140
PMID:1324639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188852/
Abstract

Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less than or equal to 2.0 micrograms/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation.

摘要

对496株产β-内酰胺酶的厌氧革兰氏阴性杆菌进行阿莫西林、阿莫西林-BRL 42715、阿莫西林-克拉维酸、替马沙星和克林霉素的琼脂稀释法最低抑菌浓度（MIC）测试，结果显示，90%受试菌株对阿莫西林的MIC为256.0微克/毫升，对阿莫西林-BRL 42715和阿莫西林-克拉维酸为2.0微克/毫升，对替马沙星和克林霉素为4.0微克/毫升。阿莫西林、替马沙星和克林霉素抑制了所有44株β-内酰胺酶阴性菌株（90%受试菌株的MIC小于或等于2.0微克/毫升）。BRL 42715不会再研发，但替马沙星值得进行临床评估。

相似文献

1
Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin.540株厌氧革兰氏阴性杆菌对阿莫西林、阿莫西林 - BRL 42715、阿莫西林 - 克拉维酸、替马沙星和克林霉素的敏感性。
Antimicrob Agents Chemother. 1992 May;36(5):1140-3. doi: 10.1128/AAC.36.5.1140.
2
Susceptibilities of 428 gram-positive and -negative anaerobic bacteria to Bay y3118 compared with their susceptibilities to ciprofloxacin, clindamycin, metronidazole, piperacillin, piperacillin-tazobactam, and cefoxitin.428株革兰氏阳性和阴性厌氧菌对Bay y3118的敏感性及其对环丙沙星、克林霉素、甲硝唑、哌拉西林、哌拉西林-他唑巴坦和头孢西丁的敏感性比较。
Antimicrob Agents Chemother. 1993 Aug;37(8):1649-54. doi: 10.1128/AAC.37.8.1649.
3
[Experimental and clinical studies on BRL 25000 (clavulanic acid-amoxicillin) in the pediatric field].
Jpn J Antibiot. 1985 Feb;38(2):342-58.
4
[In vitro susceptibilities of BRL 25000 (clavulanic acid-amoxicillin) against causative organisms in the field of obstetrics and gynecology].[BRL 25000（克拉维酸-阿莫西林）对妇产科领域致病微生物的体外敏感性]
Jpn J Antibiot. 1986 Mar;39(3):842-52.
5
Activity of telithromycin (HMR 3647) against anaerobic bacteria compared to those of eight other agents by time-kill methodology.通过时间杀菌法比较泰利霉素（HMR 3647）与其他八种药物对厌氧菌的活性。
Antimicrob Agents Chemother. 1999 Aug;43(8):2027-31. doi: 10.1128/AAC.43.8.2027.
6
beta-Lactamase production and susceptibility of US and European anaerobic gram-negative bacilli to beta-lactams and other agents.美国和欧洲厌氧革兰氏阴性杆菌的β-内酰胺酶产生情况及其对β-内酰胺类药物和其他药物的敏感性
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1081-93. doi: 10.1007/BF01967803.
7
Sensitivity of clinical isolates from German hospitals to amoxicillin/clavulanic acid (Augmentin) compared with other antibiotics.德国医院临床分离株对阿莫西林/克拉维酸（安灭菌）与其他抗生素的敏感性比较。
Chemotherapy. 1988;34(4):332-40. doi: 10.1159/000238588.
8
[Laboratory and clinical studies of BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field].[BRL 25000（克拉维酸-阿莫西林）颗粒剂在儿科领域的实验室及临床研究]
Jpn J Antibiot. 1985 Feb;38(2):431-40.
9
Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers.来自美国28个中心的320株非脆弱拟杆菌属拟杆菌分离株和129株梭杆菌属细菌的β-内酰胺酶产生情况以及对阿莫西林、阿莫西林-克拉维酸、替卡西林、替卡西林-克拉维酸、头孢西丁、亚胺培南和甲硝唑的敏感性。
Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. doi: 10.1128/AAC.34.8.1546.
10
In vitro activity of amoxycillin/clavulanate and ticarcillin/clavulanate compared with that of other antibiotics against anaerobic bacteria: comparison with the results of the 1987 survey.阿莫西林/克拉维酸和替卡西林/克拉维酸与其他抗生素对厌氧菌的体外活性比较：与1987年调查结果的对比
Acta Clin Belg. 1996;51(2):70-9. doi: 10.1080/17843286.1996.11718489.

引用本文的文献

1
In vitro activities of cefminox against anaerobic bacteria compared with those of nine other compounds.头孢米诺对厌氧菌的体外活性与其他九种化合物的比较。
Antimicrob Agents Chemother. 1998 Mar;42(3):495-501. doi: 10.1128/AAC.42.3.495.
2
Quinolone activity against anaerobes: microbiological aspects.喹诺酮对厌氧菌的活性：微生物学方面。
Drugs. 1995;49 Suppl 2:76-80. doi: 10.2165/00003495-199500492-00012.
3
Susceptibilities of 428 gram-positive and -negative anaerobic bacteria to Bay y3118 compared with their susceptibilities to ciprofloxacin, clindamycin, metronidazole, piperacillin, piperacillin-tazobactam, and cefoxitin.428株革兰氏阳性和阴性厌氧菌对Bay y3118的敏感性及其对环丙沙星、克林霉素、甲硝唑、哌拉西林、哌拉西林-他唑巴坦和头孢西丁的敏感性比较。
Antimicrob Agents Chemother. 1993 Aug;37(8):1649-54. doi: 10.1128/AAC.37.8.1649.
4
Activity of WY-49605 compared with those of amoxicillin, amoxicillin-clavulanate, imipenem, ciprofloxacin, cefaclor, cefpodoxime, cefuroxime, clindamycin, and metronidazole against 384 anaerobic bacteria.WY-49605与阿莫西林、阿莫西林-克拉维酸、亚胺培南、环丙沙星、头孢克洛、头孢泊肟、头孢呋辛、克林霉素及甲硝唑对384株厌氧菌的活性比较。
Antimicrob Agents Chemother. 1994 Nov;38(11):2599-604. doi: 10.1128/AAC.38.11.2599.
5
beta-Lactamase production and susceptibility of US and European anaerobic gram-negative bacilli to beta-lactams and other agents.美国和欧洲厌氧革兰氏阴性杆菌的β-内酰胺酶产生情况及其对β-内酰胺类药物和其他药物的敏感性
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1081-93. doi: 10.1007/BF01967803.

本文引用的文献

1
Survey of anaerobic susceptibility patterns in Canada.加拿大厌氧菌药敏模式调查。
Antimicrob Agents Chemother. 1986 Nov;30(5):798-801. doi: 10.1128/AAC.30.5.798.
2
Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones.盐酸替马沙星（A-62254）与两种氟喹诺酮类对照品的抗菌活性比较
Antimicrob Agents Chemother. 1987 Nov;31(11):1768-74. doi: 10.1128/AAC.31.11.1768.
3
Comparative activity of beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with beta-lactams against beta-lactamase-producing anaerobes.β-内酰胺酶抑制剂YTR 830、克拉维酸和舒巴坦与β-内酰胺联合应用对产β-内酰胺酶厌氧菌的比较活性
Antimicrob Agents Chemother. 1986 Nov;30(5):789-91. doi: 10.1128/AAC.30.5.789.
4
In vitro evaluation of BRL 42715, a novel beta-lactamase inhibitor.新型β-内酰胺酶抑制剂BRL 42715的体外评估
Antimicrob Agents Chemother. 1989 Sep;33(9):1580-7. doi: 10.1128/AAC.33.9.1580.
5
The in-vitro activity, pharmacokinetics and tissue penetration of temafloxacin.替马沙星的体外活性、药代动力学及组织穿透性。
J Antimicrob Chemother. 1989 Sep;24(3):415-24. doi: 10.1093/jac/24.3.415.
6
Susceptibility of Bacteroides non-fragilis and fusobacteria to amoxicillin, amoxicillin/clavulanate, ticarcillin, ticarcillin/clavulanate, cefoxitin, imipenem and metronidazole.非脆弱拟杆菌和梭杆菌对阿莫西林、阿莫西林/克拉维酸、替卡西林、替卡西林/克拉维酸、头孢西丁、亚胺培南和甲硝唑的敏感性。
Eur J Clin Microbiol Infect Dis. 1990 Jun;9(6):417-21. doi: 10.1007/BF01979473.
7
Evaluation of two methods for rapid testing for beta-lactamase production in Bacteroides and Fusobacterium.两种用于快速检测拟杆菌属和梭杆菌属中β-内酰胺酶产生的方法的评估。
Eur J Clin Microbiol Infect Dis. 1990 Jan;9(1):47-50. doi: 10.1007/BF01969535.
8
Beta-lactamase production, beta-lactam sensitivity and resistance to synergy with clavulanate of 737 Bacteroides fragilis group organisms from thirty-three US centres.来自美国33个中心的737株脆弱拟杆菌属微生物的β-内酰胺酶产生情况、β-内酰胺敏感性以及与克拉维酸协同作用的耐药性
J Antimicrob Chemother. 1990 Sep;26(3):361-70. doi: 10.1093/jac/26.3.361.
9
Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers.来自美国28个中心的320株非脆弱拟杆菌属拟杆菌分离株和129株梭杆菌属细菌的β-内酰胺酶产生情况以及对阿莫西林、阿莫西林-克拉维酸、替卡西林、替卡西林-克拉维酸、头孢西丁、亚胺培南和甲硝唑的敏感性。
Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. doi: 10.1128/AAC.34.8.1546.
10
In vitro susceptibilities of oral pigmented Bacteroides species to trospectomycin and other selected antimicrobial agents.口腔色素拟杆菌对曲氟沙星及其他选定抗菌剂的体外敏感性
Antimicrob Agents Chemother. 1990 Aug;34(8):1597-9. doi: 10.1128/AAC.34.8.1597.