Yoon Jinho, Cho Hyeon-Yeol, Shin Minkyu, Choi Hye Kyu, Lee Taek, Choi Jeong-Woo
Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, 04107, Republic of Korea.
J Mater Chem B. 2020 Aug 26;8(33):7303-7318. doi: 10.1039/d0tb01325k.
As the interest in wearable devices has increased recently, increasing biosensor flexibility has begun to attract considerable attention. Among the various types of biosensors, electrochemical biosensors are uniquely suited for the development of such flexible biosensors due to their many advantages, including their fast response, inherent miniaturization, convenient operation, and portability. Therefore, many studies on flexible electrochemical biosensors have been conducted in recent years to achieve non-invasive and real-time monitoring of body fluids such as tears, sweat, and saliva. To achieve this, various substrates, novel nanomaterials, and detection techniques have been utilized to develop conductive flexible platforms that can be applied to create flexible electrochemical biosensors. In this review, we discussed recently reported flexible electrochemical biosensors and divided them into specific categories including materials for flexible substrate, fabrication techniques for flexible biosensor development, and recently developed flexible electrochemical biosensors to externally monitor target molecules, thereby providing a means to noninvasively examine cells and body fluid samples. In conclusion, this review will discuss the materials, methods, recent studies, and perspectives on flexible electrochemical biosensors for healthcare monitoring and wearable biosensing systems.
近年来，随着人们对可穿戴设备的兴趣日益浓厚，提高生物传感器的柔韧性开始备受关注。在各类生物传感器中，电化学生物传感器因其具有诸多优势，如响应速度快、固有小型化、操作便捷以及便于携带等，特别适合用于开发此类柔性生物传感器。因此，近年来开展了许多关于柔性电化学生物传感器的研究，以实现对眼泪、汗液和唾液等体液的无创实时监测。为达成这一目标，人们利用了各种基材、新型纳米材料和检测技术来开发导电柔性平台，用于制造柔性电化学生物传感器。在本综述中，我们讨论了近期报道的柔性电化学生物传感器，并将它们分为特定类别，包括柔性基材材料、柔性生物传感器开发的制造技术，以及最近开发的用于外部监测目标分子的柔性电化学生物传感器，从而提供一种无创检测细胞和体液样本的方法。总之，本综述将讨论用于医疗保健监测和可穿戴生物传感系统的柔性电化学生物传感器的材料、方法、近期研究以及展望。
