Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey.
Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
J Periodontal Res. 2020 Dec;55(6):895-904. doi: 10.1111/jre.12782. Epub 2020 Jul 9.
The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography.
Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. To provide a more consistent data pool and stronger evidence, there is a need for studies with standard measurements and diagnostic criteria.
309 patients, who consulted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography, were enrolled to this study. Individuals were grouped based on their coronary angiography results, as CAD (+) (n = 233) and CAD (-) (n = 76). Studied parameters included cardiovascular risk factors, plaque index (PI), remaining teeth count, bleeding on probing (BOP), and probing pocket depth (PPD). Periapical radiographs were taken from teeth with ≥4 mm PPD. Oral status was categorized as periodontally healthy subjects/patients with gingivitis (Group 1), patients with periodontitis (Group 2), and edentulous subjects (Group 3).
PI (P < 0.001), PPD (P = 0.001), BOP (P = 0.004), the number of patients with less than 10 teeth (P = 0.014), and edentulism (P = 0.009) were significantly higher in CAD (+) patients, who were mostly older (P < 0.001) and male (P < 0.001). Multivariate logistic regression analysis revealed that Group 2 (odds ratio = 2.48, 95% confidence interval = 1.24-4.95, P = 0.010) and Group 3 (odds ratio = 2.01, 95% confidence interval = 1.14-5.17, P = 0.040) were highly associated with CAD. Two and three stenosed vessels were significantly higher in Groups 2 and 3 compared to Group 1 (P = 0.003).
It was found that both edentulism and periodontitis were related to CAD.
本研究旨在探讨通过血管造影诊断的口腔状况与冠状动脉疾病（CAD）严重程度之间的关系。
先前的研究表明，牙周炎和牙齿缺失与动脉粥样硬化和 CAD 有关。然而，由于结果的多样性和不同的诊断方法，并未发现明确的关联。为了提供更一致的数据池和更有力的证据，需要采用具有标准测量和诊断标准的研究。
本研究纳入了 309 名前往安卡拉大学医学院心脏病学系进行冠状动脉造影的患者。根据冠状动脉造影结果将患者分为 CAD（+）组（n=233）和 CAD（-）组（n=76）。研究参数包括心血管危险因素、斑块指数（PI）、剩余牙齿数、探诊出血（BOP）和探诊深度（PPD）。对 PPD 大于等于 4mm 的牙齿进行根尖片拍摄。根据口腔状况将患者分为牙周健康受试者/患有牙龈炎的患者（第 1 组）、患有牙周炎的患者（第 2 组）和无牙患者（第 3 组）。
CAD（+）患者的 PI（P<0.001）、PPD（P=0.001）、BOP（P=0.004）、牙齿少于 10 颗的患者比例（P=0.014）和无牙状态（P=0.009）显著更高，且这些患者年龄更大（P<0.001）且男性居多（P<0.001）。多变量逻辑回归分析显示，第 2 组（比值比=2.48，95%置信区间=1.24-4.95，P=0.010）和第 3 组（比值比=2.01，95%置信区间=1.14-5.17，P=0.040）与 CAD 显著相关。与第 1 组相比，第 2 组和第 3 组的 2 个和 3 个狭窄血管的比例显著更高（P=0.003）。
本研究发现，无牙状态和牙周炎均与 CAD 相关。
