Wang Zhongxiu, Bao Jiaqi, Yang Yuting, Wei Yingming, Li Chen, Pan Yaping, Chen Lili
Department of Periodontology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Department of Periodontology, School and Hospital of Stomatology, China Medical University, Shenyang 110002, China.
Int J Dent. 2025 Aug 23;2025:3694736. doi: 10.1155/ijod/3694736. eCollection 2025.
Periodontitis, a highly prevalent chronic inflammatory disease caused by bacteria. Cardiovascular disease (CVD) is responsible for more than 17 million deaths globally each year. Both periodontitis and CVD are global noncommunicable diseases that share common risk factors. This review aimed to provide a guide for dentists and physicians, and improved treatment regimens for patients with both periodontitis and CVDs. This present review reports existing evidence in the literature to summarize the correlation between periodontitis and six types of CVD, discusses the existing epidemiological evidence, intermechanism connections, and the impact of periodontal therapy on cardiovascular health. Current research has emphasized the potential importance of periodontitis as a risk factor for CVD and has revealed various mechanisms of interaction between the two conditions. These mechanisms include oxidative stress, immune-inflammatory responses, and dysbiosis of the oral microbiota. Periodontitis may directly or indirectly induce systemic inflammation and oxidative stress by altering the circulation of oral microbiota, thereby affecting the occurrence and development of CVD. By strengthening prevention strategies of periodontitis, we have the potential to prevent or ameliorate cardiovascular conditions. The review provides new perspectives and an indication of future directions for the prevention of CVD.
牙周炎是一种由细菌引起的高度流行的慢性炎症性疾病。心血管疾病（CVD）每年在全球导致超过1700万人死亡。牙周炎和心血管疾病都是全球性的非传染性疾病，具有共同的风险因素。本综述旨在为牙医和医生提供指导，并为患有牙周炎和心血管疾病的患者改进治疗方案。本综述报告了文献中的现有证据，以总结牙周炎与六种心血管疾病之间的相关性，讨论现有的流行病学证据、相互作用机制以及牙周治疗对心血管健康的影响。当前的研究强调了牙周炎作为心血管疾病风险因素的潜在重要性，并揭示了这两种疾病之间的各种相互作用机制。这些机制包括氧化应激、免疫炎症反应和口腔微生物群失调。牙周炎可能通过改变口腔微生物群的循环直接或间接诱导全身炎症和氧化应激，从而影响心血管疾病的发生和发展。通过加强牙周炎的预防策略，我们有可能预防或改善心血管疾病。该综述为心血管疾病的预防提供了新的视角和未来方向的指示。
