Department of Medical, Surgical, and Experimental Sciences, University of Sassari , Sassari, Italy.
Azienda Ospedaliero-Universitaria Di Sassari , Sassari, Italy.
Ophthalmic Epidemiol. 2021 Feb;28(1):39-47. doi: 10.1080/09286586.2020.1791349. Epub 2020 Jul 10.
To evaluate the role of some complete blood cell count (CBC)-derived measures in retinal vein occlusion (RVO).
This was a retrospective case-control study, including 127 newly diagnosed RVO patients and 127 sex- and age-matched subjects without RVO. A blood sample was obtained and a complete blood cell count was performed. Neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells‒neutrophils)], and platelet/lymphocyte ratio (PLR) were calculated. We also performed a meta-analysis of the available data, ours included, on the correlation between mean platelet volume (MPV) and RVO. Standardized mean differences (SMD) were used to build forest plots and assess differences in MPV values between RVO patients and controls.
Median MPV and red cell distribution width (RDW) were 8.7 fL (IQR = 7.8-9.5) and 13.2% (IQR = 12.4-14.2) in RVO patients and 7.8 fL (IQR = 7.1-8.5) and 13% (IQR = 12-14) in controls. RVO patients had significantly higher values of MPV ( < .0001) and RDW ( = .005). There were no significant differences between the values of white blood cells, lymphocytes, neutrophils, platelets, NLR, dNLR, and PLR. Multivariable logistic regression analysis revealed a statistically significant correlation between increased MPV and RVO (OR = 1.74, 95% CI = 1.38-2.2, < .0001). 519 RVO patients and 414 controls from 6 case-control studies were included in the meta-analysis. Pooled results disclosed that MPV values were significantly higher in RVO patients (SMD = 0.41 fL, 95% CI = 0.04-0.79, = .032), but extreme heterogeneity was observed (I = 86.1%, < .001).
Results suggest lack of association between CBC-derived inflammatory indices and RVO. Conversely, MPV and, to a lesser extent, RDW may be disease biomarkers in RVO.
评估一些全血细胞计数（CBC）衍生指标在视网膜静脉阻塞（RVO）中的作用。
这是一项回顾性病例对照研究，纳入了 127 例新诊断的 RVO 患者和 127 例性别和年龄匹配的无 RVO 患者。采集血样并进行全血细胞计数。计算中性粒细胞/淋巴细胞比值（NLR）、衍生 NLR [dNLR=中性粒细胞/（白细胞-中性粒细胞）]和血小板/淋巴细胞比值（PLR）。我们还对包括我们在内的现有数据进行了荟萃分析，以评估平均血小板体积（MPV）与 RVO 之间的相关性。使用标准化均数差值（SMD）构建森林图，并评估 RVO 患者和对照组之间 MPV 值的差异。
RVO 患者的中位 MPV 和红细胞分布宽度（RDW）分别为 8.7 fL（IQR=7.8-9.5）和 13.2%（IQR=12.4-14.2），对照组分别为 7.8 fL（IQR=7.1-8.5）和 13%（IQR=12-14）。RVO 患者的 MPV（<0.0001）和 RDW（=0.005）值显著升高。白细胞、淋巴细胞、中性粒细胞、血小板、NLR、dNLR 和 PLR 值之间无显著差异。多变量逻辑回归分析显示，MPV 升高与 RVO 之间存在统计学显著相关性（OR=1.74，95%CI=1.38-2.2，<0.0001）。纳入了 6 项病例对照研究的 519 例 RVO 患者和 414 例对照者。汇总结果显示，RVO 患者的 MPV 值显著升高（SMD=0.41 fL，95%CI=0.04-0.79，=0.032），但存在极高的异质性（I=86.1%，<0.001）。
结果提示，CBC 衍生的炎症指标与 RVO 之间无关联。相反，MPV 且在较小程度上 RDW 可能是 RVO 的疾病生物标志物。
