Kazantzis Dimitrios, Machairoudia Genovefa, Kroupis Christos, Theodossiadis George, Theodossiadis Panagiotis, Chatziralli Irini
2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Attikon University Hospital, 1, Rimini street, Haidari, 12462, Athens, Greece.
Department of Clinical Biochemistry, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Ophthalmol Ther. 2022 Jun;11(3):1241-1249. doi: 10.1007/s40123-022-00511-0. Epub 2022 May 3.
This study evaluated complete blood count-derived inflammation indices in patients with retinal vein occlusion (RVO).
Participants in this case-control study were 54 patients with RVO and 54 age- and sex-matched control subjects. All participants underwent a thorough ophthalmic examination, as well as blood sample testing for complete blood count. Comparison of all parameters derived from complete blood count as well as calculation of specific indices was performed between patients with RVO and controls.
Patients with RVO presented significantly higher white blood cell count (p = 0.033), neutrophil count (p = 0.003), neutrophil-to-lymphocyte ratio (NLR, p = 0.002), red cell distribution width (RDW, p = 0.009), mean platelet volume (MPV, p = 0.023), and systemic immune-inflammatory index (SII, p = 0.007) compared to controls. Receiver operator characteristic curve (ROC) analysis showed that NLR was superior to other inflammatory indices, having the greatest area under the curve. The optimal cutoff value for NLR to predict RVO was 2.29 with 46.2% sensitivity and 77.8% specificity.
Patients with RVO presented increased NLR, RDW, MPV, and SII, providing evidence that inflammation plays an important role in the pathogenesis of RVO. Complete blood cell count-derived indices can be easily calculated and may serve as an easy, simple, and cost-effective tool to evaluate the degree of systemic inflammation in patients with RVO, so as to potentially guide treatment.
本研究评估了视网膜静脉阻塞（RVO）患者全血细胞计数衍生的炎症指标。
本病例对照研究的参与者为54例RVO患者和54例年龄及性别匹配的对照者。所有参与者均接受了全面的眼科检查以及全血细胞计数的血液样本检测。对RVO患者和对照者之间全血细胞计数得出的所有参数进行了比较，并计算了特定指标。
与对照组相比，RVO患者的白细胞计数（p = 0.033）、中性粒细胞计数（p = 0.003）、中性粒细胞与淋巴细胞比值（NLR，p = 0.002）、红细胞分布宽度（RDW，p = 0.009）、平均血小板体积（MPV，p = 0.023）和全身免疫炎症指数（SII，p = 0.007）显著更高。受试者工作特征曲线（ROC）分析表明，NLR优于其他炎症指标，曲线下面积最大。预测RVO的NLR最佳截断值为2.29，敏感性为46.2%，特异性为77.8%。
RVO患者的NLR、RDW、MPV和SII升高，这证明炎症在RVO的发病机制中起重要作用。全血细胞计数衍生的指标易于计算，可作为评估RVO患者全身炎症程度的简便、简单且经济有效的工具，从而有可能指导治疗。
