精细调谐普鲁士蓝基纳米粒子及其在疾病治疗中的应用。
Finely tuned Prussian blue-based nanoparticles and their application in disease treatment.
机构信息
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China.
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
J Mater Chem B. 2020 Aug 19;8(32):7121-7134. doi: 10.1039/d0tb01248c.
The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours. Compared with other nanomaterials, PB-based nanoparticles (NPs) exhibit several unparalleled advantages in biomedical applications. This review begins with the chemical composition and physicochemical properties of PB-based NPs. The tuning strategies of PB-based NPs and their biomedical properties are systemically demonstrated. Afterwards, the biomedical applications of PB-based NPs are comprehensively recounted, mainly focusing on treatment of tumors, bacterial infection and inflammatory diseases. Finally, the challenges and future prospects of PB-based NPs and their application in disease treatment are discussed.
普鲁士蓝（PB）基纳米结构是一种具有优异生物安全性、显著光热效应和多种酶模拟行为的混合价配位网络。与其他纳米材料相比，基于 PB 的纳米粒子（NPs）在生物医学应用中具有一些无与伦比的优势。本综述首先介绍了 PB 基 NPs 的化学组成和物理化学性质。系统地展示了 PB 基 NPs 的调谐策略及其生物医学特性。随后，全面叙述了 PB 基 NPs 的生物医学应用，主要集中在肿瘤、细菌感染和炎症性疾病的治疗上。最后，讨论了 PB 基 NPs 面临的挑战和未来前景及其在疾病治疗中的应用。
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