甲芬那酸：一种被低估的抗风湿药？

Mefenamic acid: an under-rated antirheumatic?

作者信息

Mavrikakis M E, MacLeod M, Buchanan W W, Hernandez L A, Rennie J A

出版信息

Curr Med Res Opin. 1977;4(8):535-9. doi: 10.1185/03007997709115267.

Abstract

A double-blind crossover study was carried out in 18 patients with classical rheumatoid arthritis to assess the effectiveness of mefenamic acid (500 mg t.d.s.) compared with placebo or indomethacin (25 mg q.d.s.). Each treatment was given for 1 week and subjective and objective assessments were carried out at the end of each period. Results showed that both mefenamic acid and indomethacin were significantly better than placebo in most parameters. Although duration of morning stiffness and patient preference favoured indomethacin it was considered that there was no demonstrable difference of any clinical significance between the two active medications.

摘要

对18例典型类风湿性关节炎患者进行了一项双盲交叉研究，以评估甲芬那酸（500毫克，每日三次）与安慰剂或吲哚美辛（25毫克，每日四次）相比的疗效。每种治疗给药1周，并在每个疗程结束时进行主观和客观评估。结果显示，在大多数参数方面，甲芬那酸和吲哚美辛均显著优于安慰剂。虽然晨僵持续时间和患者偏好更倾向于吲哚美辛，但认为两种活性药物之间没有任何具有临床意义的明显差异。