Doheny Image Reading Center, Doheny Eye Institute.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
J Glaucoma. 2020 Oct;29(10):975-980. doi: 10.1097/IJG.0000000000001599.
PRéCIS:: Our study demonstrated that in low-tension glaucoma (LTG) patients, Microperimeter-3 (MP-3)-derived and Humphrey Field Analyzer (HFA)-derived retinal sensitivities were similar and strongly correlated, allowing the respective data to be interrelated.
To compare and correlate retinal sensitivities obtained by Nidek MP-3 with those obtained from the HFA in eyes with LTG.
In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the 2 devices.
No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31 dB; range, 13.05 to 31.60 vs. HFA: 26.42±3.98 dB; range, 17.17 to 30.96), and a strong correlation (r=0.66, P<0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP-3 versus HFA-derived mean deviation (r=0.57, P<0.001), as well as, the pattern standard deviation (r=0.67, P<0.001). The intraclass correlation coefficient was excellent (ICC=0.80, 95% confidence interval, 0.63-0.89), while the Bland-Altman analysis showed good agreement between the 2 devices with respect to retinal sensitivity.
Retinal sensitivity measurements obtained by the MP-3 microperimetry instrument and the standard automated HFA perimeter were similar and highly correlated in patients with LTG. Given the potential benefits of microperimetry technology such as auto-eye-tracking and potentially more precise structure-function correlations, the use of microperimetry to monitor visual function in glaucoma management warrants further consideration.
我们的研究表明，在低眼压性青光眼（LTG）患者中，微视野计 3 型（MP-3）和 Humphrey 视野分析仪（HFA）测量的视网膜敏感度相似且相关性强，允许将各自的数据相互关联。
比较和关联在 LTG 患者中使用 Nidek MP-3 获得的视网膜敏感度和使用 HFA 获得的视网膜敏感度。
在这项前瞻性对照研究中，24 例 LTG 患者的 45 只眼在加利福尼亚大学洛杉矶分校-多尼眼科中心接受了 MP-3（尼德克技术公司）和 HFA（卡尔蔡司医学技术公司）的视网膜敏感度评估。比较和关联了两种设备的全局和点测量视网膜敏感度。
两种设备测量的平均视网膜敏感度无统计学差异（P=0.85）（MP-3：26.33±4.31dB；范围 13.05 至 31.60 与 HFA：26.42±3.98dB；范围 17.17 至 30.96），并且注意到视网膜敏感度测量具有很强的相关性（r=0.66，P<0.001）。此外，在 MP-3 得出的平均视网膜敏感度与 HFA 得出的平均偏差（r=0.57，P<0.001）之间以及在模式标准差（r=0.67，P<0.001）之间观察到中度至强相关性。组内相关系数为优秀（ICC=0.80，95%置信区间 0.63-0.89），而 Bland-Altman 分析表明两种设备之间在视网膜敏感度方面具有良好的一致性。
在 LTG 患者中，MP-3 微视野计和标准自动化 HFA 周边仪获得的视网膜敏感度相似且高度相关。鉴于微视野计技术的潜在优势，例如自动眼球追踪和可能更精确的结构-功能相关性，使用微视野计监测青光眼管理中的视觉功能值得进一步考虑。
