低眼压性青光眼中小视野计与自动视野计视网膜敏感度的比较与相关性。
Comparison and Correlation of Retinal Sensitivity Between Microperimetry and Standard Automated Perimetry in Low-tension Glaucoma.
机构信息
Doheny Image Reading Center, Doheny Eye Institute.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
出版信息
J Glaucoma. 2020 Oct;29(10):975-980. doi: 10.1097/IJG.0000000000001599.
UNLABELLED
PRéCIS:: Our study demonstrated that in low-tension glaucoma (LTG) patients, Microperimeter-3 (MP-3)-derived and Humphrey Field Analyzer (HFA)-derived retinal sensitivities were similar and strongly correlated, allowing the respective data to be interrelated.
PURPOSE
To compare and correlate retinal sensitivities obtained by Nidek MP-3 with those obtained from the HFA in eyes with LTG.
MATERIALS AND METHODS
In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the 2 devices.
RESULTS
No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31 dB; range, 13.05 to 31.60 vs. HFA: 26.42±3.98 dB; range, 17.17 to 30.96), and a strong correlation (r=0.66, P<0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP-3 versus HFA-derived mean deviation (r=0.57, P<0.001), as well as, the pattern standard deviation (r=0.67, P<0.001). The intraclass correlation coefficient was excellent (ICC=0.80, 95% confidence interval, 0.63-0.89), while the Bland-Altman analysis showed good agreement between the 2 devices with respect to retinal sensitivity.
CONCLUSION
Retinal sensitivity measurements obtained by the MP-3 microperimetry instrument and the standard automated HFA perimeter were similar and highly correlated in patients with LTG. Given the potential benefits of microperimetry technology such as auto-eye-tracking and potentially more precise structure-function correlations, the use of microperimetry to monitor visual function in glaucoma management warrants further consideration.
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要点
我们的研究表明，在低眼压性青光眼（LTG）患者中，微视野计 3 型（MP-3）和 Humphrey 视野分析仪（HFA）测量的视网膜敏感度相似且相关性强，允许将各自的数据相互关联。
目的
比较和关联在 LTG 患者中使用 Nidek MP-3 获得的视网膜敏感度和使用 HFA 获得的视网膜敏感度。
材料和方法
在这项前瞻性对照研究中，24 例 LTG 患者的 45 只眼在加利福尼亚大学洛杉矶分校-多尼眼科中心接受了 MP-3（尼德克技术公司）和 HFA（卡尔蔡司医学技术公司）的视网膜敏感度评估。比较和关联了两种设备的全局和点测量视网膜敏感度。
结果
两种设备测量的平均视网膜敏感度无统计学差异（P=0.85）（MP-3：26.33±4.31dB；范围 13.05 至 31.60 与 HFA：26.42±3.98dB；范围 17.17 至 30.96），并且注意到视网膜敏感度测量具有很强的相关性（r=0.66，P<0.001）。此外，在 MP-3 得出的平均视网膜敏感度与 HFA 得出的平均偏差（r=0.57，P<0.001）之间以及在模式标准差（r=0.67，P<0.001）之间观察到中度至强相关性。组内相关系数为优秀（ICC=0.80，95%置信区间 0.63-0.89），而 Bland-Altman 分析表明两种设备之间在视网膜敏感度方面具有良好的一致性。
结论
在 LTG 患者中，MP-3 微视野计和标准自动化 HFA 周边仪获得的视网膜敏感度相似且高度相关。鉴于微视野计技术的潜在优势，例如自动眼球追踪和可能更精确的结构-功能相关性，使用微视野计监测青光眼管理中的视觉功能值得进一步考虑。
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