Zamin Hasnat, Yabutsuka Takeshi, Takai Shigeomi, Sakaguchi Hiroshi
Graduate School of Energy Science, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Materials (Basel). 2020 Jul 8;13(14):3045. doi: 10.3390/ma13143045.
Zirconia is a well-known bioceramic for dental and orthopedic applications due to its mechanical and aesthetic properties. However, it lacks sufficient bioactivity to bond with the living bone. This study was aimed to induce bioactivity to tetragonal zirconia polycrystal (3Y-TZP) by simple biomimetic aqueous solution treatment. First, hydrofluoric acid (HF) etching was performed to enhance the surface roughness of the 3Y-TZP surface. Then, the samples were treated with two types of aqueous solutions containing calcium and phosphate ions (Ca-P solutions); one solution additionally contained magnesium (Mg) ions and the other without Mg ions. Finally, hydroxyapatite (HAp)-forming ability was evaluated by the conventional simulated body fluid (SBF) test, and the effect of Mg ions on the adhesive strength of the HAp layer to the roughened 3Y-TZP surface was also investigated. The results concluded that there were no noticeable differences in the effect of Mg ions on the HAp-forming ability, and both types of solution treatments resulted in dense HAp formation in 1 day SBF immersion. However, incorporation of Mg ions in one of the Ca-P solutions significantly improved the adhesive strength of the HAp layer to the HF-etched 3Y-TZP substrate compared to the Ca-P solution with no Mg ions.
由于其机械性能和美学特性，氧化锆是一种用于牙科和骨科应用的知名生物陶瓷。然而，它缺乏与活骨结合的足够生物活性。本研究旨在通过简单的仿生水溶液处理赋予四方氧化锆多晶体（3Y-TZP）生物活性。首先，进行氢氟酸（HF）蚀刻以提高3Y-TZP表面的粗糙度。然后，将样品用两种含钙离子和磷酸根离子的水溶液（Ca-P溶液）处理；一种溶液还含有镁（Mg）离子，另一种不含Mg离子。最后，通过传统的模拟体液（SBF）试验评估羟基磷灰石（HAp）形成能力，并研究Mg离子对HAp层与粗糙化的3Y-TZP表面之间粘附强度的影响。结果表明，Mg离子对HAp形成能力的影响没有明显差异，两种溶液处理在1天的SBF浸泡中均导致致密的HAp形成。然而，与不含Mg离子的Ca-P溶液相比，在一种Ca-P溶液中加入Mg离子显著提高了HAp层与HF蚀刻的3Y-TZP基底之间的粘附强度。
