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诊断病例。躯干上的浸润区域。

Case for diagnosis. Infiltrated areas on the trunk.

作者信息

Góes Larissa Daniele Machado, Scrignoli Juliana Alves, Morais Patrícia, Talhari Carolina

机构信息

Tropical Dermatology Clinic, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Rheumatology Service, Fundação Hospital Adriano Jorge, Manaus, AM, Brazil.

出版信息

An Bras Dermatol. 2020 Sep-Oct;95(5):652-654. doi: 10.1016/j.abd.2019.12.007. Epub 2020 Jun 25.

DOI:10.1016/j.abd.2019.12.007
PMID:32651045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7562998/
Abstract

Leprosy is an infectious disease with chronic evolution, caused by Mycobacterium leprae, an acid-fast bacillus that mainly affects the skin and peripheral nervous tissue. Many of the clinical manifestations of leprosy can mimic connective tissue diseases. The authors present the case of a 49-year-old woman who had been treated for four years for systemic lupus erythematosus in a rheumatological service. Skin biopsy of a plaque on the inguinal region was compatible with borderline lepromatous leprosy associated with a type 1 lepra reaction. The patient is undergoing treatment with multibacillary multidrug therapy, showing clinical improvement.

摘要

麻风是一种具有慢性病程的传染病,由麻风分枝杆菌引起,这是一种抗酸杆菌,主要影响皮肤和周围神经组织。麻风的许多临床表现可类似于结缔组织疾病。作者报告了一例49岁女性病例,该患者在风湿病科接受系统性红斑狼疮治疗已四年。腹股沟区斑块的皮肤活检结果符合界线类偏瘤型麻风伴1型麻风反应。该患者正在接受多菌型联合化疗,临床症状有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/f2832b068566/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/0d07324d9373/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/3885424fed36/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/b960c6310963/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/f2832b068566/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/0d07324d9373/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/3885424fed36/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/b960c6310963/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79e/7562998/f2832b068566/gr4.jpg

相似文献

1
Case for diagnosis. Infiltrated areas on the trunk.诊断病例。躯干上的浸润区域。
An Bras Dermatol. 2020 Sep-Oct;95(5):652-654. doi: 10.1016/j.abd.2019.12.007. Epub 2020 Jun 25.
2
Incidence of late lepra reaction among multibacillary leprosy patients after MDT.多菌型麻风患者在接受多药联合化疗后迟发性麻风反应的发生率。
Int J Lepr Other Mycobact Dis. 1995 Mar;63(1):18-22.
3
Leprosy pseudoimbricata: an unusual presentation of steroid-modified borderline lepromatous leprosy.麻风假叠瓦状疹:类固醇修饰的界线类偏瘤型麻风的一种不寻常表现。
Int J Dermatol. 2020 Apr;59(4):e124-e125. doi: 10.1111/ijd.14783. Epub 2020 Jan 20.
4
Two microbiological relapses in a patient with lepromatous leprosy.一名瘤型麻风患者出现两次微生物学复发。
Lepr Rev. 2008 Sep;79(3):331-4.
5
The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.多菌型麻风患者血清麻风分枝杆菌特异性抗原对化疗的反应。
Am J Trop Med Hyg. 1991 Jun;44(6):702-8. doi: 10.4269/ajtmh.1991.44.702.
6
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man.一名中国男性的界线类偏瘤型麻风伴1型(逆向)反应
Am J Trop Med Hyg. 2015 Aug;93(2):207-209. doi: 10.4269/ajtmh.14-0491.
7
Histopathologic observations on the persistence of Mycobacterium leprae in the skin of multibacillary leprosy patients under chemotherapy.化疗期间多菌型麻风患者皮肤中麻风分枝杆菌持续存在的组织病理学观察
Lepr Rev. 1988 Dec;59(4):341-6. doi: 10.5935/0305-7518.19880042.
8
Case for diagnosis. Erythematous and infiltrated plaques in the infrahyoid region.诊断病例。舌骨下区域出现红斑及浸润性斑块。
An Bras Dermatol. 2021 Jan-Feb;96(1):97-99. doi: 10.1016/j.abd.2020.03.022. Epub 2020 Nov 20.
9
Relapses during long-term follow up with drug-susceptible M. leprae among multibacillary leprosy patients treated with multidrug therapy regimens; case reports.多菌型麻风患者采用多药联合治疗方案治疗后,在对药物敏感的麻风分枝杆菌长期随访期间出现复发;病例报告
Int J Lepr Other Mycobact Dis. 1995 Sep;63(3):391-4.
10
Borderline lepromatous leprosy presenting as a single cutaneous plaque.呈现为单个皮肤斑块的界线类偏瘤型麻风。
Australas J Dermatol. 2005 Aug;46(3):181-3. doi: 10.1111/j.1440-0960.2005.00175.x.

本文引用的文献

1
Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients.麻风病:现状、临床及实验室方面、治疗史以及对所有患者采用统一多药疗法的前景。
An Bras Dermatol. 2017 Nov-Dec;92(6):761-773. doi: 10.1590/abd1806-4841.20176724.
2
Multibacillary leprosy mimicking systemic lupus erythematosus: case report and literature review.酷似系统性红斑狼疮的多菌型麻风:病例报告及文献综述
Lupus. 2015 Sep;24(10):1095-102. doi: 10.1177/0961203315574557. Epub 2015 Mar 10.
3
Anti-cyclic citrullinated peptide antibodies and rheumatoid factor sera titers in leprosy patients from Mexico.
墨西哥麻风病患者的抗环瓜氨酸肽抗体和类风湿因子血清滴度。
Rheumatol Int. 2012 Nov;32(11):3531-6. doi: 10.1007/s00296-011-2224-0. Epub 2011 Nov 15.
4
[Application of the diagnostic criteria for systemic lupus erythematosus to patients with multibacillary leprosy].
Rev Soc Bras Med Trop. 2011 Jan-Feb;44(1):85-90. doi: 10.1590/s0037-86822011000100019.
5
Leprosy-related joint involvement.麻风相关的关节受累
Clin Rheumatol. 2009 Jan;28(1):79-84. doi: 10.1007/s10067-008-0986-x. Epub 2008 Sep 19.
6
Increased incidence of cytoplasmic ANCA (cANCA) and other autoantibodies in leprosy patients from western India.印度西部麻风病患者中细胞质抗中性粒细胞胞质抗体(cANCA)及其他自身抗体的发病率增加。
Lepr Rev. 2004 Mar;75(1):50-6.
7
Antiphospholipid antibodies in leprotic patients: a correlation with disease manifestations.麻风病患者中的抗磷脂抗体:与疾病表现的相关性。
Clin Exp Rheumatol. 2000 Jul-Aug;18(4):492-4.
8
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient.一名印度患者的界线类偏瘤型麻风病中的头皮弥漫性脱发。
Lepr Rev. 1997 Dec;68(4):336-40. doi: 10.5935/0305-7518.19970043.
9
The rheumatic manifestations of leprosy (Hansen disease).麻风(汉森病)的风湿性表现。
Medicine (Baltimore). 1980 Nov;59(6):442-8. doi: 10.1097/00005792-198011000-00004.