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诊断病例。舌骨下区域出现红斑及浸润性斑块。

Case for diagnosis. Erythematous and infiltrated plaques in the infrahyoid region.

作者信息

Bezerra Natália Tenório Cavalcante, Schettini Antonio Pedro Mendes, Leturiondo André Luiz, Mathias Liana Hortencia Miranda Tubilla

机构信息

Fundação Alfredo da Matta, Manaus, AM, Brazil.

Fundação Alfredo da Matta, Manaus, AM, Brazil.

出版信息

An Bras Dermatol. 2021 Jan-Feb;96(1):97-99. doi: 10.1016/j.abd.2020.03.022. Epub 2020 Nov 20.

DOI:10.1016/j.abd.2020.03.022
PMID:33288364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7838112/
Abstract

Leprosy is a chronic infectious disease caused by Mycobacterium leprae and, depending on the host immune status, presents different clinical forms. This report describes the case of a 46-year-old man who had hypoesthetic lesions in the infrahyoid region for 30 days. The bacilloscopy was negative. The anatomopathological examination showed alterations corresponding to the tuberculoid pole (epithelioid histiocytes) and virchowian pole (foamy histiocytes), compatible with borderline-virchowian leprosy (Ridley and Jopling classification). Rapid tests for HIV I, II, and syphilis were positive, with a CD4 count of 223. The patient started treatment with multibacillary multidrug therapy, antiretroviral therapy, and benzathine penicillin, with marked clinical improvement in two months.

摘要

麻风病是一种由麻风分枝杆菌引起的慢性传染病,根据宿主免疫状态的不同,会呈现出不同的临床形式。本报告描述了一名46岁男性的病例,该患者在舌骨下区域出现感觉减退性病变30天。细菌涂片检查为阴性。解剖病理学检查显示病变对应于结核样型(上皮样组织细胞)和维丘型(泡沫状组织细胞),符合界线类偏维丘型麻风(里德利和乔普林分类法)。HIV I、II和梅毒快速检测均为阳性,CD4细胞计数为223。患者开始接受多菌型联合化疗、抗逆转录病毒治疗和苄星青霉素治疗,两个月后临床症状明显改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/d9166521a2c4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/9334a6c1a119/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/753ea3d8f47e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/d9166521a2c4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/9334a6c1a119/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/753ea3d8f47e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/7838112/d9166521a2c4/gr4.jpg

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本文引用的文献

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Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients.麻风病:现状、临床及实验室方面、治疗史以及对所有患者采用统一多药疗法的前景。
An Bras Dermatol. 2017 Nov-Dec;92(6):761-773. doi: 10.1590/abd1806-4841.20176724.
2
Viral Co-infection and Leprosy Outcomes: A Cohort Study.病毒合并感染与麻风病结局:一项队列研究。
PLoS Negl Trop Dis. 2015 Aug 12;9(8):e0003865. doi: 10.1371/journal.pntd.0003865. eCollection 2015.
3
WHO Expert Committee on Leprosy.世界卫生组织麻风病专家委员会
World Health Organ Tech Rep Ser. 2012(968):1-61, 1 p following 61.