Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany
Institute of Clinical Neurobiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
J Neurosci. 2020 Aug 12;40(33):6289-6308. doi: 10.1523/JNEUROSCI.0288-20.2020. Epub 2020 Jul 10.
Motor learning depends on synaptic plasticity between corticostriatal projections and striatal medium spiny neurons. Retrograde tracing from the dorsolateral striatum reveals that both layer II/III and V neurons in the motor cortex express BDNF as a potential regulator of plasticity in corticostriatal projections in male and female mice. The number of these BDNF-expressing cortical neurons and levels of BDNF protein are highest in juvenile mice when adult motor patterns are shaped, while BDNF levels in the adult are low. When mice are trained by physical exercise in the adult, BDNF expression in motor cortex is reinduced, especially in layer II/III projection neurons. Reduced expression of cortical BDNF in 3-month-old mice results in impaired motor learning while space memory is preserved. These findings suggest that activity regulates BDNF expression differentially in layers II/III and V striatal afferents from motor cortex and that cortical BDNF is essential for motor learning. Motor learning in mice depends on corticostriatal BDNF supply, and regulation of BDNF expression during motor learning is highest in corticostriatal projection neurons in cortical layer II/III.
运动学习依赖于皮质纹状体投射和纹状体中间多棘神经元之间的突触可塑性。从背外侧纹状体的逆行追踪显示，雄性和雌性小鼠的运动皮层中的 II/III 层和 V 层神经元均表达 BDNF，作为皮质纹状体投射中可塑性的潜在调节剂。在形成成年运动模式时，幼年小鼠中这些表达 BDNF 的皮质神经元数量和 BDNF 蛋白水平最高，而成年小鼠中的 BDNF 水平较低。当成年小鼠通过体育锻炼进行训练时，运动皮层中的 BDNF 表达会重新诱导，特别是在 II/III 层投射神经元中。3 个月大的小鼠皮质 BDNF 表达减少会导致运动学习受损，而空间记忆得以保留。这些发现表明，活动在来自运动皮层的 II/III 层和 V 层纹状体传入纤维中以不同的方式调节 BDNF 表达，并且皮质 BDNF 对于运动学习是必不可少的。小鼠的运动学习依赖于皮质纹状体 BDNF 的供应，并且在运动学习期间，BDNF 表达的调节在皮质 II/III 层的皮质纹状体投射神经元中最高。
