Laboratory of Immunology, G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
Laboratory of Enzyme Chemistry, G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia.
Bull Exp Biol Med. 2020 Jun;169(2):246-248. doi: 10.1007/s10517-020-04860-3. Epub 2020 Jul 10.
Adjuvant activity of fucoidans in experimental vaccine compositions with ovalbumin was studied on a mouse model. Compositions with sulfated polysaccharides from brown alga Fucus evanescens (native fucoidan in combination with polyphenols, and a product of fucoidan enzymatic hydrolysis) induced multiple productions of antigen-specific antibodies - total IgG, its isotypes IgG1 and, especially, IgG2a, in comparison with an individual ovalbumin. The adjuvant effect of native and structurally modified fucoidans is slightly inferior to that of the traditional licensed aluminum hydroxide adjuvant. The results indicate the prospects of using sulfated polysaccharides from F. evanescens as adjuvants in vaccines.
我们在小鼠模型上研究了褐藻岩藻聚糖在含卵清蛋白实验性疫苗组合物中的佐剂活性。与单独的卵清蛋白相比，来自褐藻 Fucus evanescens 的含硫酸多糖的组合物（天然岩藻聚糖与多酚结合物，以及岩藻聚糖酶解产物）诱导了多种抗原特异性抗体的产生 - 总 IgG、其同种型 IgG1 和尤其是 IgG2a。天然和结构修饰的岩藻聚糖的佐剂效应略低于传统许可的氢氧化铝佐剂。这些结果表明，使用 F. evanescens 的硫酸多糖作为疫苗佐剂具有前景。
