Mravec Boris, Tibensky Miroslav, Horvathova Lubica
Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Slovakia; Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Slovakia.
J Neuroimmunol. 2020 Jul 3;346:577312. doi: 10.1016/j.jneuroim.2020.577312.
Accumulated evidence has confirmed the ability of stress to promote the induction and progression of cancer (for review see Stress and cancer. Part I: Mechanisms mediating the effect of stressors on cancer). In support of this, data from clinical trials utilizing approaches that reduce stress-related signaling have shown prolonged survival of cancer patients. Therefore, the question has arisen as to how we can utilize this knowledge in the daily treatment of cancer patients. The main aim of this review is to critically analyze data from studies utilizing psychotherapy or treatment by β-blockers on the survival of cancer patients. Because these approaches, especially treatment by β-blockers, have been routinely used in clinical practice for decades in the treatment of non-cancer patients, their wider introduction into oncology might be realized in the near future.
越来越多的证据证实了压力促进癌症诱发和进展的能力（有关综述见《压力与癌症。第一部分：介导应激源对癌症影响的机制》）。与此相符的是，利用减少应激相关信号传导方法的临床试验数据表明，癌症患者的生存期得以延长。因此，出现了一个问题，即我们如何在癌症患者的日常治疗中利用这一知识。本综述的主要目的是批判性地分析利用心理治疗或β受体阻滞剂治疗对癌症患者生存期影响的研究数据。由于这些方法，尤其是β受体阻滞剂治疗，已经在临床实践中常规用于治疗非癌症患者数十年了，因此在不久的将来可能会更广泛地应用于肿瘤学领域。
