Department of General Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy.
Department of General Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy; PNC - Padova Neuroscience Center, University of Padova, Via Orus 2, 35131 Padova, Italy.
Brain Cogn. 2020 Aug;143:105599. doi: 10.1016/j.bandc.2020.105599. Epub 2020 Jul 8.
This study aimed to investigate emotional alterations in a community sample with primary psychopathic traits. Sixty males selected from a larger sample and divided in two groups, High (HP) and Low (LP) primary Psychopathy, watched 15 validated emotional movies divided in five categories (Erotic, Neutral, Fear, and the new Scenery and Compassion). Subjective responses and cortical activity in the EEG Gamma band (30-49 Hz) were recorded. Concerning self-reports, HP participants felt less anxious and anguished in response to Fear clips and less sad, touched and anguished by Compassion excerpts. Negative clips induced larger EEG Gamma activity in both groups compared to neutral and erotic movies, but Gamma activity to Fear movies was reduced in HP. This group showed also a small cortical response to positive Scenery movies, at the level of the Neutral ones. Source analysis showed in HP participants a reduced cortical activation to Fear in a large brain network, comprising the right prefrontal and temporal cortices and bilateral inferior parietal cortex. Results showed that primary psychopathy, in addition to the impaired response to Fear, was associated with a reduced response also to other specific categories of emotional stimuli, suggesting an altered affect on a broader scale.
本研究旨在调查具有原发性精神病特征的社区样本中的情绪变化。从更大的样本中选择的 60 名男性被分为两组，高（HP）和低（LP）原发性精神病，并观看了 15 个经过验证的情绪电影，分为五类（色情、中性、恐惧、新风景和同情）。记录了主观反应和 EEG 伽马波段（30-49Hz）的皮质活动。关于自我报告，与恐惧片段相比，HP 参与者在恐惧片段中感到焦虑和痛苦较少，而在同情片段中感到悲伤、感动和痛苦较少。与中性和色情电影相比，两组人在观看负面片段时，EEG 伽马活动较大，但 HP 组观看恐惧电影时伽马活动减少。该组对积极的风景电影也表现出较小的皮质反应，与中性电影的水平相当。源分析显示，在 HP 参与者中，对恐惧的大脑皮层反应减少，涉及到右侧前额叶和颞叶以及双侧下顶叶皮层的一个大型脑网络。结果表明，原发性精神病除了对恐惧的反应受损外，还与对其他特定类别的情绪刺激的反应减少有关，这表明在更广泛的范围内存在情感改变。
