Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
J Hosp Infect. 2020 Oct;106(2):283-294. doi: 10.1016/j.jhin.2020.07.007. Epub 2020 Jul 10.
The high demand for personal protective equipment during the novel coronavirus outbreak has prompted the need to develop strategies to conserve supply. Little is known regarding decontamination interventions to allow for surgical mask reuse.
To identify and synthesize data from original research evaluating interventions to decontaminate surgical masks for the purpose of reuse.
MEDLINE, Embase, CENTRAL, Global Health, the WHO COVID-19 database, Google Scholar, DisasterLit, preprint servers, and prominent journals from inception to April 8, 2020, were searched for prospective original research on decontamination interventions for surgical masks. Citation screening was conducted independently in duplicate. Study characteristics, interventions, and outcomes were extracted from included studies by two independent reviewers. Outcomes of interest included impact of decontamination interventions on surgical mask performance and germicidal effects.
Seven studies met eligibility criteria: one evaluated the effects of heat and chemical interventions applied after mask use on mask performance, and six evaluated interventions applied prior to mask use to enhance antimicrobial properties and/or mask performance. Mask performance and germicidal effects were evaluated with heterogeneous test conditions. Safety outcomes were infrequently evaluated. Mask performance was best preserved with dry heat decontamination. Good germicidal effects were observed in salt-, N-halamine-, and nanoparticle-coated masks.
There is limited evidence on the safety or efficacy of surgical mask decontamination. Given the heterogeneous methods used in studies to date, we are unable to draw conclusions on the most efficacious and safe intervention for decontaminating surgical masks.
新型冠状病毒爆发期间，个人防护设备的需求量很大，这促使人们需要制定策略来节约供应。对于消毒干预措施以允许重复使用外科口罩，人们知之甚少。
确定并综合评估用于重复使用的外科口罩消毒干预措施的原始研究数据。
从 2020 年 4 月 8 日开始，检索 MEDLINE、Embase、CENTRAL、全球卫生、世界卫生组织 COVID-19 数据库、Google Scholar、DisasterLit、预印本服务器和知名期刊，以获取有关外科口罩消毒干预措施的前瞻性原始研究。独立重复进行引文筛选。两名独立审查员从纳入的研究中提取研究特征、干预措施和结果。感兴趣的结果包括消毒干预措施对手术口罩性能和杀菌效果的影响。
有 7 项研究符合入选标准：一项评估了口罩使用后应用热和化学干预措施对口罩性能的影响，六项评估了在口罩使用前应用干预措施以增强抗菌性能和/或口罩性能的干预措施。口罩性能和杀菌效果采用不同的测试条件进行评估。安全性结果很少被评估。干热消毒可最大程度地保留口罩性能。在盐、N-卤胺和纳米粒子涂层口罩中观察到良好的杀菌效果。
关于外科口罩消毒的安全性或效果的数据有限。鉴于迄今为止研究中使用的方法具有异质性，我们无法就消毒外科口罩最有效和最安全的干预措施得出结论。
