Macleod M A, Adkisson G H, Fox M J, Pearson R R
Department of Nuclear Medicine, Royal Naval Hospital.
Br J Radiol. 1988 Dec;61(732):1106-9. doi: 10.1259/0007-1285-61-732-1106.
Cerebral barotrauma, or the neurological manifestation of the "bends", is a relatively common disease of divers and aviators. To date, however, no-one has succeeded in demonstrating a cerebral or spinal cord lesion in vivo following a decompression incident, despite the presence of definitive clinical signs and symptoms of central nervous system involvement. This paper describes the use of 99Tcm-labelled hexamethylpropyleneamine oxime (99Tcm-HMPAO) with single photon emission tomography in a study of three individuals involved in driving accidents. All three suffered cerebral barotrauma during decompression and all exhibited clinical signs and symptoms of dysbarism to a varying degree. Imaging was performed at time intervals ranging from 2 h to several days following the incidents. The results showed well defined cerebral ischaemic lesions in all three subjects. We conclude that 99Tcm-HMPAO imaging provides a significant advance in locating and demonstrating cerebral lesions following barotrauma and will contribute greatly to our understanding of the pathophysiological processes involved.
脑气压伤，即“减压病”的神经学表现，是潜水员和飞行员中相对常见的一种疾病。然而，迄今为止，尽管存在明确的中枢神经系统受累的临床体征和症状，但没有人能够在减压事件后在体内证实存在脑或脊髓损伤。本文描述了在一项针对三名交通事故受害者的研究中，使用99锝标记的六甲基丙烯胺肟（99Tcm-HMPAO）进行单光子发射断层扫描的情况。这三人在减压过程中均遭受脑气压伤，且都不同程度地表现出气压伤的临床体征和症状。在事件发生后的2小时至数天内的不同时间间隔进行了成像检查。结果显示，所有三名受试者均有明确的脑缺血性损伤。我们得出结论，99Tcm-HMPAO成像在定位和显示气压伤后脑损伤方面取得了重大进展，并将极大地有助于我们对所涉及的病理生理过程的理解。
