Wenzhou Central Hospital, Wenzhou, Zhejiang 32035 China.
School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Clin Chim Acta. 2020 Nov;510:105-110. doi: 10.1016/j.cca.2020.07.015. Epub 2020 Jul 10.
COVID-19 infection is epidemic worldwide. We describe the serum lipid profile of the patients with COVID-19 infection.
In this retrospective study, we collected the first clinical laboratory data of 114 patients on admission, and 80 healthy controls. Meanwhile, we monitored the serum lipid profile, COVID-19 nucleic acid and chest CT scan of a severe patient from the early stage of infection to the recovery period for a total of 80 days.
Compared with the healthy controls, the patients had sharply decreased concentrations of total cholesterol, HDL-cholesterol and LDL-cholesterol (P < 0.001). Among the patients, HDL-cholesterol concentration in severe groups was significantly lower than the common groups [1.01 (0.88-1.20) vs 1.21 (1.02-1.48) mmol/l, P < 0.001]. The lipid profile of a severe patient showed that serum cholesterol concentration significantly decreased in the early stage and returned to be normal in the recovery period. Moreover, the change of HDL-cholesterol in this patient was consistent with the results of nucleic acid tests and chest CT scans. In correlation analysis, HDL-cholesterol concentration was negatively correlated with C-reactive protein (CRP, r = -0.396, P < 0.001) and positively correlated with lymphocytes (r = 0.336, P < 0.001). The area under curve (AUC) in receiver operating characteristic (ROC) of HDL-cholesterol was 0.732 (P < 0.001), and, the adjusted odd ratio (OR) of HDL-cholesterol was 0.023 (95% CI 0.002-0.227).
Decreased serum HDL-cholesterol is associated with the severity of COVID-19 infection.
COVID-19 感染在全球范围内流行。我们描述了 COVID-19 感染患者的血清脂质谱。
在这项回顾性研究中，我们收集了 114 名入院患者和 80 名健康对照者的首次临床实验室数据。同时，我们监测了一名重症患者从感染早期到恢复期共 80 天的血清脂质谱、COVID-19 核酸和胸部 CT 扫描。
与健康对照组相比，患者的总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇浓度明显降低（P<0.001）。在患者中，重症组的高密度脂蛋白胆固醇浓度明显低于普通组[1.01（0.88-1.20）比 1.21（1.02-1.48）mmol/L，P<0.001]。重症患者的血脂谱显示，血清胆固醇浓度在早期显著降低，在恢复期恢复正常。此外，该患者的高密度脂蛋白胆固醇变化与核酸检测和胸部 CT 扫描结果一致。在相关性分析中，高密度脂蛋白胆固醇浓度与 C 反应蛋白（CRP，r=-0.396，P<0.001）呈负相关，与淋巴细胞呈正相关（r=0.336，P<0.001）。高密度脂蛋白胆固醇在接收者操作特征（ROC）曲线下的面积（AUC）为 0.732（P<0.001），高密度脂蛋白胆固醇的调整比值比（OR）为 0.023（95%CI 0.002-0.227）。
血清高密度脂蛋白胆固醇降低与 COVID-19 感染的严重程度有关。
