评价单独肌内注射氯胺酮和氟烷酮、氯胺酮-氟烷酮和氟烷酮-丁丙诺啡-美托咪定对普通狨猴（Callithrix jacchus）的麻醉和心肺作用。
Evaluation of anaesthetic and cardiorespiratory effects after intramuscular administration of alfaxalone alone, alfaxalone-ketamine and alfaxalone-butorphanol-medetomidine in common marmosets (Callithrix jacchus).
机构信息
Primate Research Institute, Kyoto University, Aichi, Japan.
Institute for Tropical Biology and Conservation, University Malaysia Sabh, Sabah, Malaysia.
出版信息
J Med Primatol. 2020 Dec;49(6):291-299. doi: 10.1111/jmp.12482. Epub 2020 Jul 12.
BACKGROUND
Anaesthesia is often required in common marmosets undergoing various procedures. The aim of this study was to evaluate anaesthetic and cardiopulmonary effects of alfaxalone, alfaxalone-ketamine and alfaxalone-butorphanol-medetomidine in common marmosets.
METHODS
The following treatments were repeatedly administered to seven female common marmosets: Treatment A, alfaxalone (12 mg kg ) alone; treatment AK, alfaxalone (1 mg animal ) plus ketamine (2.5 mg animal ); treatment AMB, alfaxalone (4 mg kg ), medetomidine (50 µg kg ) plus butorphanol (0.3 mg kg ); and treatment AMB-Ati, AMB with atipamezole at 45 minutes.
RESULTS AND CONCLUSIONS
Marmosets became laterally recumbent and unresponsive for approximately 30 minutes in A and AK and for approximately 60 minutes in AMB. The animals showed rapid recovery following atipamezole injection in AMB-Ati. The decrease in heart rate and SpO was significantly greater in AMB compared to A and AK. Oxygen supplementation, anaesthetic monitors and atipamezole should be available especially when AMB is administered.
背景
在进行各种手术时，常需要对普通绒猴进行麻醉。本研究旨在评估氟烷酮、氟烷酮-氯胺酮和氟烷酮-丁丙诺啡-美托咪定在普通绒猴中的麻醉和心肺作用。
方法
对 7 只雌性普通绒猴反复给予以下治疗：A 组，单独给予氟烷酮（12mg/kg）；AK 组，氟烷酮（1mg 动物）加氯胺酮（2.5mg 动物）；AMB 组，氟烷酮（4mg/kg），美托咪定（50μg/kg）加丁丙诺啡（0.3mg/kg）；AMB-Ati 组，45 分钟时给予 AMB 加阿替美唑。
结果和结论
A 和 AK 组中，绒猴侧卧且无反应约 30 分钟，AMB 组中约 60 分钟。AMB-Ati 组中，在给予阿替美唑后，动物恢复迅速。与 A 和 AK 相比，AMB 组的心率和 SpO2 下降明显更大。尤其是在给予 AMB 时，应提供氧气补充、麻醉监测和阿替美唑。
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