Westermann J, Pabst R
Center of Anatomy, Medical School of Hannover, Federal Republic of Germany.
Res Exp Med (Berl). 1988;188(4):267-76. doi: 10.1007/BF01852275.
After splenic autotransplantation both weight and blood flow of the regenerated splenic tissue are decreased. In addition, the protective function of the transplant is less compared to that of the normal spleen. In the present study, the red pulp of normal and transplanted splenic tissue was stimulated by injections of phenylhydrazine to increase the weight, the blood flow, and the protective function. After stimulation, the weight of the normal spleen increased to 900 +/- 70 mg (control 530 +/- 20 mg) and the transplanted tissue to 240 +/- 70 mg (control 70 +/- 20 mg). This enlargement was caused by an increase in the splenic red pulp. However, the relative blood flow decreased in both the normal spleen and the transplant to 50% of the normal value. To evaluate the protective function of the stimulated splenic tissue, normal, splenectomized and transplanted rats were infected with Plasmodium berghei. Despite the dramatic increase in the red pulp, neither the normal nor the transplanted animals showed a survival rate superior to that of the splenectomized animals. The mass of splenic tissue obviously does not correlate with the protective effect of the spleen in parasitic infections.
自体脾移植后，再生脾组织的重量和血流量均降低。此外，与正常脾脏相比，移植脾的保护功能较弱。在本研究中，通过注射苯肼刺激正常和移植脾组织的红髓，以增加其重量、血流量和保护功能。刺激后，正常脾脏重量增加至900±70mg（对照组为530±20mg），移植组织重量增加至240±70mg（对照组为70±20mg）。这种增大是由脾红髓增加所致。然而，正常脾脏和移植脾的相对血流量均降至正常值的50%。为评估刺激后脾组织的保护功能，将正常、脾切除和移植的大鼠感染伯氏疟原虫。尽管红髓显著增加，但正常组和移植组动物的存活率均未高于脾切除组动物。脾组织的质量显然与脾脏在寄生虫感染中的保护作用无关。
