Westermann J, Willführ K U, Pabst R
Centre of Anatomy, Medical School of Hannover, West Germany.
J Pediatr Surg. 1988 Sep;23(9):835-8. doi: 10.1016/s0022-3468(88)80234-3.
After splenectomy there is an increased risk of fatal overwhelming postsplenectomy sepsis, especially in children. If all alternatives to splenectomy fail, autotransplantation of splenic fragments is indicated. These fragments regenerate after a necrotic phase to small splenic nodules. Regulatory factors governing the regeneration process are largely unknown. Inbred rats were used as a model to define the influence of recipient and donor age on the regenerated mass and the blood flow of transplanted splenic fragments. These are both important factors for the protective function of the spleen. Fetal, newborn, weanling, or adult spleens were implanted into the greater omentum of newborn, weanling, or adult rats. The younger the recipient and donor, the better the regeneration and perfusion of transplants. However, these did not reach more than 40% of the normal splenic mass. In addition, no experimental group achieved more than one third of the normal splenic blood flow. There is an obvious age dependency in splenic regeneration and blood flow, but the transplants are far from attaining a normal splenic mass and perfusion.
脾切除术后发生致命性暴发性脾切除后感染的风险增加，尤其是在儿童中。如果脾切除的所有替代方案均失败，则应进行脾碎片自体移植。这些碎片在经历坏死期后会再生为小的脾结节。目前对于调控再生过程的因素仍知之甚少。本研究使用近交系大鼠作为模型，以确定受体和供体年龄对移植脾碎片的再生质量和血流量的影响。这两个因素对于脾脏的保护功能均很重要。将胎儿、新生、断奶或成年大鼠的脾脏植入新生、断奶或成年大鼠的大网膜中。受体和供体越年轻，移植脾的再生和灌注情况越好。然而，这些移植脾的质量未超过正常脾脏的40%。此外，没有一个实验组的脾血流量超过正常脾脏的三分之一。脾脏再生和血流量存在明显的年龄依赖性，但移植脾远未达到正常脾脏的质量和灌注水平。
