Pabst R, Hafke R, Hillebrand J
J Trauma. 1985 Apr;25(4):326-8. doi: 10.1097/00005373-198504000-00008.
Autologous splenic tissue regenerates after subperitoneal transplantation in laboratory animals and in man. Qualitatively it resembles normal splenic tissue but the quantity usually only attains a small proportion of the normal spleen. In the prevention of overwhelming post-splenectomy sepsis a critical mass and a considerable blood flow to the regenerated spleen seem to be essential. By increasing the work load to splenic transplants in rats, significantly more splenic tissue was regenerated. This was achieved by: stimulating the white pulp by repetitive injections of xenogeneic red cells; stimulating the red pulp by damaging red cells with phenylhydrazine; a combination of 1 and 2; and stimulating the reticuloendothelial system by IP injections of methylcellulose. Stimulating the red pulp and the reticuloendothelial system were more effective than the injection of antigens. As the splenic mass is obviously regulated by the work load, we conclude that this effect should be used to attain the critical splenic mass and to increase the blood flow for effective clearance of bacteria from the blood.
自体脾组织在实验动物和人类的腹膜下移植后能够再生。从性质上看，它类似于正常脾组织，但数量通常仅达到正常脾脏的一小部分。在预防脾切除术后暴发性感染方面，再生脾脏的临界质量和充足的血流量似乎至关重要。通过增加大鼠脾移植的工作量，再生的脾组织明显增多。这是通过以下方式实现的：通过反复注射异种红细胞刺激白髓；用苯肼破坏红细胞刺激红髓；方法1和2的组合；以及通过腹腔注射甲基纤维素刺激网状内皮系统。刺激红髓和网状内皮系统比注射抗原更有效。由于脾脏质量显然受工作量调节，我们得出结论，应利用这种效应来达到临界脾脏质量并增加血流量，以便有效地从血液中清除细菌。
