• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

CLME:一个用于不等式约束下线性混合效应模型的R包。

CLME: An R Package for Linear Mixed Effects Models under Inequality Constraints.

作者信息

Jelsema Casey M, Peddada Shyamal D

机构信息

National Institute of Environmental Health Sciences (NIEHS).

出版信息

J Stat Softw. 2016;75. doi: 10.18637/jss.v075.i01. Epub 2016 Nov 19.

DOI:10.18637/jss.v075.i01
PMID:32655332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7351245/
Abstract

In many applications researchers are typically interested in testing for inequality constraints in the context of linear fixed effects and mixed effects models. Although there exists a large body of literature for performing statistical inference under inequality constraints, user friendly statistical software for implementing such methods is lacking, especially in the context of linear fixed and mixed effects models. In this article we introduce , a package in the R language that can be used for testing a broad collection of inequality constraints. It uses residual bootstrap based methodology which is reasonably robust to non-normality as well as heteroscedasticity. The package is illustrated using two data sets. The package also contains a graphical interface built using the package.

摘要

在许多应用中,研究人员通常对在线性固定效应和混合效应模型的背景下检验不等式约束感兴趣。尽管存在大量关于在不等式约束下进行统计推断的文献,但缺乏用于实现此类方法的用户友好型统计软件,尤其是在线性固定效应和混合效应模型的背景下。在本文中,我们介绍了R语言中的一个包,它可用于检验广泛的不等式约束集合。它使用基于残差自助法的方法,该方法对非正态性和异方差性具有相当的稳健性。使用两个数据集对该包进行了说明。该包还包含一个使用 包构建的图形界面。

相似文献

1
CLME: An R Package for Linear Mixed Effects Models under Inequality Constraints.CLME:一个用于不等式约束下线性混合效应模型的R包。
J Stat Softw. 2016;75. doi: 10.18637/jss.v075.i01. Epub 2016 Nov 19.
2
Linear mixed effects models under inequality constraints with applications.带有约束条件的线性混合效应模型及其应用。
PLoS One. 2014 Jan 21;9(1):e84778. doi: 10.1371/journal.pone.0084778. eCollection 2014.
3
Multinomial Models with Linear Inequality Constraints: Overview and Improvements of Computational Methods for Bayesian Inference.具有线性不等式约束的多项模型:贝叶斯推断计算方法的概述与改进
J Math Psychol. 2019 Aug;91:70-87. doi: 10.1016/j.jmp.2019.03.004. Epub 2019 Apr 2.
4
lcc: an R package to estimate the concordance correlation, Pearson correlation and accuracy over time.LCC:一个用于估计一致性相关性、Pearson相关性及随时间变化的准确性的R软件包。
PeerJ. 2020 Sep 17;8:e9850. doi: 10.7717/peerj.9850. eCollection 2020.
5
Linear mixed-effects models for within-participant psychology experiments: an introductory tutorial and free, graphical user interface (LMMgui).用于参与者内部心理学实验的线性混合效应模型:入门教程及免费图形用户界面(LMMgui)
Front Psychol. 2015 Jan 22;6:2. doi: 10.3389/fpsyg.2015.00002. eCollection 2015.
6
The next generation of regression standardization with the R package stdReg2.使用R包stdReg2的下一代回归标准化。
Ann Epidemiol. 2025 May;105:66-74. doi: 10.1016/j.annepidem.2025.04.002. Epub 2025 Apr 8.
7
isocir: An R Package for Constrained Inference using Isotonic Regression for Circular Data, with an Application to Cell Biology.isocir:一个用于对圆形数据使用等距回归进行约束推断的R包,并应用于细胞生物学。
J Stat Softw. 2013 Aug;54(4). doi: 10.18637/jss.v054.i04.
8
MEPHAS: an interactive graphical user interface for medical and pharmaceutical statistical analysis with R and Shiny.MEPHAS:一个用于 R 和 Shiny 的医学和药物统计分析的交互式图形用户界面。
BMC Bioinformatics. 2020 May 11;21(1):183. doi: 10.1186/s12859-020-3494-x.
9
DEGGs: an R package with shiny app for the identification of differentially expressed gene-gene interactions in high-throughput sequencing data.DEGGs:一个带有 shiny 应用程序的 R 包,用于鉴定高通量测序数据中差异表达的基因-基因相互作用。
Bioinformatics. 2023 Apr 3;39(4). doi: 10.1093/bioinformatics/btad192.
10
Multibridge: an R package to evaluate informed hypotheses in binomial and multinomial models.Multibridge:一个用于评估二项式和多项式模型中明智假设的 R 包。
Behav Res Methods. 2023 Dec;55(8):4343-4368. doi: 10.3758/s13428-022-02020-1. Epub 2023 Jun 5.

引用本文的文献

1
Treatment outcome in a specialized unit for adults with severe and extreme anorexia nervosa at one-year follow up.重度及极重度神经性厌食症成年患者专科治疗单元的一年随访治疗结果
J Eat Disord. 2025 Aug 25;13(1):187. doi: 10.1186/s40337-025-01374-z.
2
Endocannabinoid and N-acylethanolamine concentrations in hair of female patients with posttraumatic stress disorder - associations with clinical symptoms and outcomes following multimodal trauma-focused inpatient treatment.创伤后应激障碍女性患者头发中的内源性大麻素和N-酰基乙醇胺浓度——与多模式创伤聚焦住院治疗后的临床症状及结果的关联
Transl Psychiatry. 2025 Aug 23;15(1):312. doi: 10.1038/s41398-025-03476-3.
3

本文引用的文献

1
Linear mixed effects models under inequality constraints with applications.带有约束条件的线性混合效应模型及其应用。
PLoS One. 2014 Jan 21;9(1):e84778. doi: 10.1371/journal.pone.0084778. eCollection 2014.
2
Statistical properties of an early stopping rule for resampling-based multiple testing.基于重抽样的多重检验早期停止规则的统计特性。
Biometrika. 2012 Dec;99(4):973-980. doi: 10.1093/biomet/ass051. Epub 2012 Oct 3.
3
Artifactual changes in Sprague-Dawley rat hematologic parameters after storage of samples at 3 °C and 21 °C.
Randomised trial reveals a mismatch between preferences for and hormonal responses to anthropogenic light colour temperatures.
随机试验揭示了对人为光色温的偏好与激素反应之间的不匹配。
PLoS One. 2025 Aug 11;20(8):e0327843. doi: 10.1371/journal.pone.0327843. eCollection 2025.
4
Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-term research site.在一个长期研究地点实施人畜共患病预防方案后,黑猩猩呼吸道疾病症状和肠道病毒数量减少。
Biol Conserv. 2025 Aug;308. doi: 10.1016/j.biocon.2025.111225. Epub 2025 May 16.
5
Prolonged Water-Only Fasting Followed by a Whole-Plant-Food Diet Promotes Fat-Free Mass Recovery and Continued Fat Mass Loss in Adults With Overweight or Obesity.长期仅饮水禁食后采用全植物性食物饮食可促进超重或肥胖成年人瘦体重恢复并持续减少脂肪量。
Obes Sci Pract. 2025 Aug 5;11(4):e70086. doi: 10.1002/osp4.70086. eCollection 2025 Aug.
6
Racial Disparities in Quality of Dental Care Among Publicly Insured Children.公共保险儿童牙科护理质量的种族差异。
Med Care. 2025 Jul 7;63(9):646-55. doi: 10.1097/MLR.0000000000002184.
7
Longitudinal dynamics of clinical and neurophysiological changes in parkinson's disease over four and a half years.帕金森病四年半临床及神经生理学变化的纵向动态研究
Sci Rep. 2025 Jul 26;15(1):27284. doi: 10.1038/s41598-025-13558-3.
8
Effects of two nAChR agonists on wood ants: acetamiprid induces lethality and immediate hypoactivity, while flupyradifurone causes time-delayed hyperactivity.两种烟碱型乙酰胆碱受体激动剂对木蚁的影响:啶虫脒可导致死亡和立即出现活动减退,而氟吡呋喃酮则引起延迟性活动亢进。
Environ Sci Pollut Res Int. 2025 Jun;32(30):18366-18379. doi: 10.1007/s11356-025-36755-z. Epub 2025 Jul 18.
9
Gene-environment interplay in the relationship between the visibility of the environment and self-reported depression in early midlife: a Finnish twin cohort study.中年早期环境可见性与自我报告的抑郁之间关系中的基因-环境相互作用:一项芬兰双胞胎队列研究
medRxiv. 2025 May 23:2025.05.23.25328215. doi: 10.1101/2025.05.23.25328215.
10
Macrophage IL-4 polarization is restricted by soluble CD40 agonists and antigen-induced CD154 but not by constitutive CD154 expressed by CD4+ T cells.巨噬细胞IL-4极化受到可溶性CD40激动剂和抗原诱导的CD154的限制,但不受CD4+ T细胞组成性表达的CD154的限制。
J Leukoc Biol. 2025 Jul 9;117(7). doi: 10.1093/jleuko/qiaf069.
将样本分别储存在3℃和21℃后,斯普拉格-道利大鼠血液学参数的人为变化。
J Am Assoc Lab Anim Sci. 2012;51(5):616-21.
4
Order-restricted inference for multivariate longitudinal data with applications to the natural history of hearing loss.有序限制推断在多变量纵向数据中的应用,以及在听力损失自然史中的应用。
Stat Med. 2012 Jul 20;31(16):1761-73. doi: 10.1002/sim.5335.
5
Constrained inference in mixed-effects models for longitudinal data with application to hearing loss.混合效应模型在纵向数据中的约束推断及其在听力损失中的应用。
Biostatistics. 2011 Apr;12(2):327-40. doi: 10.1093/biostatistics/kxq051. Epub 2010 Aug 18.
6
Growth of uterine leiomyomata among premenopausal black and white women.绝经前黑人和白人女性子宫平滑肌瘤的生长情况。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19887-92. doi: 10.1073/pnas.0808188105. Epub 2008 Dec 1.
7
The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies.经合组织验证大鼠子宫营养生物测定的计划。第2阶段:剂量反应研究。
Environ Health Perspect. 2003 Sep;111(12):1530-49. doi: 10.1289/ehp.5780.
8
Tests for order restrictions in binary data.二元数据中顺序限制的检验。
Biometrics. 2001 Dec;57(4):1219-27. doi: 10.1111/j.0006-341x.2001.01219.x.
9
A test for differences between treatment means when several dose levels are compared with a zero dose control.当将几个剂量水平与零剂量对照进行比较时,用于检验治疗均值之间差异的一种检验方法。
Biometrics. 1971 Mar;27(1):103-17.