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2019年冠状病毒病(COVID-19)大流行期间各医院患者人数和呼吸机需求的预测模型:初步技术报告

A Predictive Model for Patient Census and Ventilator Requirements at Individual Hospitals During the Coronavirus Disease 2019 (COVID-19) Pandemic: A Preliminary Technical Report.

作者信息

Epstein Richard H, Dexter Franklin

机构信息

Anesthesiology, University of Miami Miller School of Medicine, Miami, USA.

Anesthesiology, University of Iowa, Iowa City, USA.

出版信息

Cureus. 2020 Jun 8;12(6):e8501. doi: 10.7759/cureus.8501.

Abstract

During the initial wave of the coronavirus disease 2019 (COVID-19) pandemic, many hospitals struggled to forecast bed capacity and the number of mechanical ventilators they needed to have available. Numerous epidemiological models forecast regional or national peak bed and ventilator needs, but these are not suitable for predictions at the hospital level. We developed an analytical model to assist hospitals in determining their census and ventilator requirements for COVID-19 patients during future periods of the pandemic, by using their data. This model is based on (1) projection of future daily admissions using counts from the previous seven days, (2) lengths of stay and duration of mechanical ventilation, and (3) the percentage of inpatients requiring mechanical ventilation. The implementation is done within an Excel (Microsoft, Redmond, WA) workbook without the use of add-ins or macro programming. The model inputs for each currently hospitalized patient with COVID-19 are the duration of hospitalization, whether the patient is currently receiving or has previously received mechanical ventilation, and the duration of the current ventilation episode, if applicable. Data validity and internal consistency are checked within the workbook, and errors are identified. Durations of care (length of hospital stay and duration of mechanical ventilation) are generated by fitting a two-parameter Weibull distribution to the hospital's historical data from the initial phase of the pandemic (incorporating censoring due to ongoing care), for which we provide source code in the R programming language (R Foundation for Statistical Computing, Vienna, Austria). Conditional distributions are then calculated using the hospital's current data. The output of the model is nearly instantaneous, producing an estimate of the census and the number of ventilators required in one, three, and seven days following the date on which the simulation is run. Given that the pandemic is ongoing, and a second surge of cases is expected with the reopening of the economy, having such a tool to predict resource needs for hospital planning purposes has been useful. A major benefit to individual hospitals from such modeling has been to provide reassurance to state and local governments that the hospitals have sufficient resources available to meet anticipated needs for new COVID-19 patients without having to set aside substantially greater numbers of beds or ventilators for such care. Such ongoing activity is important for the economic recovery of hospitals that have been hard-hit economically by the shutdown in elective surgery and other patient care activities. The modeling software is freely available at https://FDshort.com/COVID19, and its parameters can easily be modified by end-users.

摘要

在2019年冠状病毒病(COVID-19)大流行的第一波期间,许多医院难以预测床位容量以及所需的机械通气设备数量。众多流行病学模型预测了地区或国家层面的床位和呼吸机需求峰值,但这些模型并不适用于医院层面的预测。我们开发了一个分析模型,通过使用医院自身的数据,协助医院确定在大流行未来阶段COVID-19患者的住院人数和呼吸机需求。该模型基于以下几点:(1)使用前七天的入院人数来预测未来每日入院人数;(2)住院时长和机械通气时长;(3)需要机械通气的住院患者百分比。该模型在Excel(微软公司,华盛顿州雷德蒙德)工作簿中实现,无需使用插件或宏编程。对于每一位目前住院的COVID-19患者,模型的输入数据包括住院时长、患者当前是否正在接受或此前是否接受过机械通气,以及(如适用)当前通气阶段的时长。工作簿内会检查数据有效性和内部一致性,并识别错误。通过将双参数威布尔分布拟合到医院在大流行初始阶段的历史数据(纳入因持续治疗导致的删失数据)来生成护理时长(住院时长和机械通气时长),我们在R编程语言(R统计计算基金会,奥地利维也纳)中提供了相关源代码。然后使用医院的当前数据计算条件分布。模型的输出几乎是即时的,会生成模拟运行日期后一天、三天和七天的住院人数估计值以及所需呼吸机数量估计值。鉴于大流行仍在持续,且随着经济重新开放预计会出现第二波病例激增,拥有这样一个用于医院规划目的预测资源需求的工具很有用。这种建模对各个医院的一个主要好处是,能向州和地方政府保证,医院有足够资源来满足新COVID-19患者的预期需求,而无需为此预留大量更多的床位或呼吸机。这种持续的活动对于因择期手术和其他患者护理活动的停工而在经济上受到重创的医院的经济复苏很重要。该建模软件可在https://FDshort.com/COVID19上免费获取,终端用户可轻松修改其参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02fe/7346295/0cd03353ec5c/cureus-0012-00000008501-i02.jpg

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