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扁平苔藓:新加坡72例病例研究

Lichen planus: a study of 72 cases in Singapore.

作者信息

Vijayasingam S M, Lim K B, Yeoh K H, Cheong W L, Chong Y Y, Daniel M, Lim H M

机构信息

Middle Road Hospital, Singapore.

出版信息

Ann Acad Med Singap. 1988 Oct;17(4):541-4.

PMID:3265606
Abstract

Seventy-two patients attending this hospital with a diagnosis of lichen planus were examined. There was a striking predominance of Indians (69%) and a surprisingly low incidence of Chinese (24%) and Malays (4%) in the study population, compared to the racial composition of the general clinic population. The age distribution curve of the study population was bimodal with peaks at age groups 21-30 (22%) and 41-60 (33%) years. The most common morphologic variant was lichen planus vulgaris (common type) which we observed in 46 (64%) patients, followed by lichen planus hypertrophicus in 8 (11%) and lichen planus atrophicus in 2 (3%). Lichen planus confined to the skin was observed in 49 (68%) patients. Mucous membrane involvement was seen in 21 (29%)-17 (24%) had oral mucosa membrane involvement and 4 (6%) genital mucous membrane involvement. In 16 (22%) cases, mucous membranes were exclusively involved--12 (17%) had oral mucous membrane involvement and 4 (6%) genital mucous membrane involvement. Nail changes were only observed in 2 (3%) patients. Eight (11%) patients had associated diabetes mellitus. Overall, lichen planus appeared to pursue a protracted course with only 4 (6%) patients clearing completely after a disease duration of 5-12 months.

摘要

对这家医院收治的72例诊断为扁平苔藓的患者进行了检查。与普通门诊人群的种族构成相比,研究人群中印度人占比极高(69%),而中国人(24%)和马来人(4%)的发病率出奇的低。研究人群的年龄分布曲线呈双峰型,在21 - 30岁(22%)和41 - 60岁(33%)年龄组出现峰值。最常见的形态学变异型是寻常型扁平苔藓(普通型),我们在46例(64%)患者中观察到,其次是肥厚性扁平苔藓8例(11%)和萎缩性扁平苔藓2例(3%)。49例(68%)患者仅出现皮肤扁平苔藓。21例(29%)出现黏膜受累——17例(24%)有口腔黏膜受累,4例(6%)有生殖器黏膜受累。16例(22%)病例仅出现黏膜受累——12例(17%)有口腔黏膜受累,4例(6%)有生殖器黏膜受累。仅2例(3%)患者观察到指甲改变。8例(11%)患者伴有糖尿病。总体而言,扁平苔藓似乎病程迁延,病程5 - 12个月后仅有4例(6%)患者完全痊愈。

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