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冠状病毒(COVID-19)大流行期间癌症患者的生育力保存

Fertility Preservation in Cancer Patients During the Coronavirus (COVID-19) Pandemic.

作者信息

Dellino Miriam, Minoia Carla, Paradiso Angelo Virgilio, De Palo Raffaella, Silvestris Erica

机构信息

Gynecologic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

Haematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

出版信息

Front Oncol. 2020 Jun 4;10:1009. doi: 10.3389/fonc.2020.01009. eCollection 2020.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also identified as Corona virus disease 19 (COVID-19), has recently produced a dramatic and widespread sanitary emergency. However, despite the necessity to assist a substantial number of affected patients, it is also essential to, at the same time, guarantee the usual clinical care, particularly to cancer patients, including fertility preservation (FP) strategies before the beginning of the anti-cancer treatments. The FP techniques for adult female patients include oocyte and embryo cryopreservation, which require both adequate ovarian reserve (OR) and controlled ovarian stimulation (COS) to promote multiple follicular growth. However, ovarian tissue cryopreservation is an additional FP practice suitable when an anti-cancer treatment is urgently required, whereas, for male patients, sperm cryopreservation is a simple and well-adopted procedure. Here, we focus on the current conditions in terms of agreements and rules of FP procedures during this COVID-19 pandemic to achieve and provide useful recommendations for the adoption of these techniques in patients with cancer.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2),也被称为冠状病毒病19(COVID-19),最近引发了一场严重且广泛的卫生紧急事件。然而,尽管有必要救治大量受影响的患者,但与此同时,保证常规临床护理也至关重要,尤其是对癌症患者而言,包括在抗癌治疗开始前的生育力保存(FP)策略。成年女性患者的FP技术包括卵母细胞和胚胎冷冻保存,这需要足够的卵巢储备(OR)和控制性卵巢刺激(COS)以促进多个卵泡生长。然而,当急需进行抗癌治疗时,卵巢组织冷冻保存是另一种适用的FP方法,而对于男性患者,精子冷冻保存是一种简单且广泛采用的程序。在此,我们关注在这场COVID-19大流行期间FP程序的协议和规则方面的当前状况,以便为在癌症患者中采用这些技术达成并提供有用的建议。

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