Hossein Rashidi Batool, Bandarian Mahin, Bandarian Fatemeh, Shahrokh Tehraninejad Ensieh, Jafarabadi Mina
Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2022 Mar;16(1):86-92. doi: 10.18502/jfrh.v16i1.8598.
COVID-19 pandemic has affected all aspects of human life including social, economic, healthy behaviors and even individual relationships. This study aimed to investigate the effect of corona virus outbreak on assisted reproductive technology (ART) outcome. In this retrospective and prospective cohort, 260 ART cycles of ovum pick up (OPU), fresh embryo transfer (ET) and frozen embryo transfer (FET) were evaluated in 223 women (from December 2019 to February 2020) and during COVID-19 outbreak (February and July 2020) in an infertility center. Primary and secondary outcomes of ART cycles including chemical and clinical pregnancy rate were evaluated. The mean±SD (standard deviation) age of women was 34.17±6.56 years. Chemical and clinical pregnancy rates were 23.91% (33/138) per embryo transfer and 75.8% (25/33) per positive pregnancy test, respectively while ongoing pregnancy was seen only in 69.7% (23/33) of those with positive pregnancy test. Spontaneous abortion rate was 15.15% (5/33) per laboratory pregnancy. COVID-19 symptoms were reported in 2.83% and 15.38% of women during and after ART cycles, respectively. It seems that COVID-19 pandemic has not negative effect on outcome of ART cycles except for cancelation rate due to COVID-19 that increased at the beginning of COVID-19 outbreak as it was unknown at that time and awareness was limited.
新冠疫情已经影响到人类生活的方方面面，包括社会、经济、健康行为，甚至个人关系。本研究旨在调查冠状病毒爆发对辅助生殖技术（ART）结局的影响。在这个回顾性和前瞻性队列研究中，对一家不孕不育中心的223名女性在2019年12月至2020年2月期间以及新冠疫情爆发期间（2020年2月和7月）进行的260个取卵（OPU）、新鲜胚胎移植（ET）和冷冻胚胎移植（FET）的ART周期进行了评估。评估了ART周期的主要和次要结局，包括化学妊娠率和临床妊娠率。女性的平均年龄±标准差为34.17±6.56岁。每个胚胎移植的化学妊娠率和临床妊娠率分别为23.91%（33/138）和每个阳性妊娠试验为75.8%（25/33），而只有69.7%（23/33）的阳性妊娠试验者出现持续妊娠。每例实验室妊娠的自然流产率为15.15%（5/33）。在ART周期期间和之后，分别有2.83%和15.38%的女性报告有新冠症状。似乎新冠疫情除了在疫情爆发初期因新冠导致的取消率增加外，对ART周期的结局没有负面影响，因为当时情况不明且认识有限。
