Ren Huiwen, Wang Qiuyue
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
Department of Endocrinology, the First Hospital Affiliated of China Medical University, Shenyang, China.
DNA Cell Biol. 2021 Apr;40(4):553-567. doi: 10.1089/dna.2020.5973. Epub 2021 Mar 17.
Diabetic kidney disease (DKD) is one of the most common chronic microvascular complications of diabetes. In addition to the characteristic clinical manifestations of proteinuria, it also has a complex pathological process that results from the combined effects of multiple factors involving the whole renal structure such as glomeruli, renal tubules, and blood vessels. Non-coding RNAs (ncRNA) are transcripts with no or low coding potential, among which micro RNA (miRNA) has been widely studied as a functional miRNA involved in regulation and a potential biomarker for disease prediction. The abundance of long coding RNA (lncRNA) is highly expressed with a certain degree of research progress, but the structural similarity makes the research still challenging. The research of circular RNA (circRNA) is still in its early stages. It is more relevant to the study to provide a more relevant link between diseases in the kidney and other tissues or organs. This classification review mainly summarized the biogenesis characteristics, the pathological mechanism of ncRNA-regulating diseases, the ways of ncRNA in the clinical prediction as a potential biomarker, and the interaction networks of ncRNA.
糖尿病肾病（DKD）是糖尿病最常见的慢性微血管并发症之一。除了蛋白尿这一特征性临床表现外，它还具有复杂的病理过程，该过程是由涉及整个肾脏结构（如肾小球、肾小管和血管）的多种因素共同作用导致的。非编码RNA（ncRNA）是编码潜力无或低的转录本，其中微小RNA（miRNA）作为参与调控的功能性miRNA和疾病预测的潜在生物标志物已得到广泛研究。长链编码RNA（lncRNA）丰度高表达且有一定研究进展，但结构相似性使得研究仍具有挑战性。环状RNA（circRNA）的研究仍处于早期阶段。提供肾脏疾病与其他组织或器官疾病之间更相关联系的研究更具相关性。本分类综述主要总结了ncRNA的生物发生特征、ncRNA调控疾病的病理机制、ncRNA作为潜在生物标志物在临床预测中的方式以及ncRNA的相互作用网络。
