Kayser Reilly R, Snorrason Ivar, Haney Margaret, Lee Francis S, Simpson H Blair
Department of Psychiatry, New York State Psychiatric Institute, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
Department of Psychiatry, Weill Cornell Medical College, New York, New York.
Cannabis Cannabinoid Res. 2019 Jun 14;4(2):77-87. doi: 10.1089/can.2018.0049. eCollection 2019.
Obsessive-compulsive disorder (OCD) is a disabling illness that is associated with significant functional impairment. Although evidence-based pharmacotherapies exist, currently available medications are ineffective in some patients and may cause intolerable side effects in others. There is an urgent need for new treatments. A growing body of basic and clinical research has showed that the endocannabinoid system (ECS) plays a role in anxiety, fear, and repetitive behaviors. At the same time, some patients with OCD who smoke cannabis anecdotally report that it relieves their symptoms and mitigates anxiety, and several case reports describe patients whose OCD symptoms improved after they were treated with cannabinoids. Taken together, these findings suggest that the ECS could be a potential target for novel medications for OCD. In this study, we review evidence from both animal and human studies that suggests that the ECS may play a role in OCD and related disorders. We also describe findings from studies in which cannabinoid drugs were shown to impact symptoms of these conditions. An emerging body of evidence suggests that the ECS plays a role in OCD symptoms and may be a target for the development of novel medications. Further exploration of this topic through well-designed human trials is warranted.
强迫症（OCD）是一种致残性疾病，与严重的功能损害相关。尽管存在循证药物疗法，但目前可用的药物对一些患者无效，且可能在其他患者中引起难以忍受的副作用。迫切需要新的治疗方法。越来越多的基础和临床研究表明，内源性大麻素系统（ECS）在焦虑、恐惧和重复行为中起作用。同时，一些患有强迫症的大麻吸食者称大麻能缓解他们的症状并减轻焦虑，一些病例报告描述了患者在接受大麻素治疗后强迫症症状有所改善。综合来看，这些发现表明ECS可能是治疗强迫症新药的潜在靶点。在本研究中，我们回顾了来自动物和人体研究的证据，这些证据表明ECS可能在强迫症及相关疾病中起作用。我们还描述了大麻素药物对这些病症症状有影响的研究结果。越来越多的证据表明，ECS在强迫症症状中起作用，可能是新型药物开发的靶点。有必要通过精心设计的人体试验对这一主题进行进一步探索。
