Faculdades Integradas de Patos, R. Horácio Nóbrega, S/N, Belo Horizonte, 58704-000, Brazil.
Post Graduate Program in Dentistry, State University of Paraíba, R. Baraúnas, 351 - Bairro Universitário, Campina Grande, PB, 58429-500, Brazil.
Lasers Med Sci. 2020 Dec;35(9):1899-1907. doi: 10.1007/s10103-020-03100-4. Epub 2020 Jul 12.
To perform an integrative review of the literature on the effectiveness of intravascular laser irradiation of blood (ILIB) as an adjunct therapy in the treatment of chronic systemic diseases. This is an integrative literature review that included non-randomized and randomized controlled clinical trials that specifically evaluated the therapeutic effect of ILIB on chronic systemic diseases, without restriction of time, and written in English. The Medical Publications (PubMed)/MEDLINE database was used. MeSH (Medical Subject Headings) was used to select search descriptors with the Boolean operators "AND/OR." After applying the inclusion and exclusion criteria, 13 articles were selected. Coronary diseases were the most prevalent, followed by type 2 diabetes mellitus, with the coronary artery being the most widely used access route for ILIB application. Despite the varied parameters and protocols for using this kind of therapy, all studies have shown satisfactory results in the patients' clinical condition. ILIB proved to be effective in all organic systems, showing some positive result. However, studies on the effect of this therapy on various diseases are still scarce in the literature, and there is a need for more well-designed clinical trials to better understand the role of ILIB in various systemic diseases.
对血管内激光辐照血液（ILIB）作为慢性全身性疾病治疗辅助疗法的有效性的文献进行综合评价。这是一项综合文献回顾，包括非随机和随机对照临床试验，专门评估 ILIB 对慢性全身性疾病的治疗效果，不限制时间，且用英文撰写。使用了医学出版物（PubMed）/MEDLINE 数据库。使用了医学主题词（MeSH），并用布尔运算符“AND/OR”选择搜索描述符。在应用纳入和排除标准后，选择了 13 篇文章。冠心病最为常见，其次是 2 型糖尿病，ILIB 应用最广泛的入路是冠状动脉。尽管这种治疗方法的参数和方案各不相同，但所有研究都表明患者的临床状况有了令人满意的结果。ILIB 在所有有机系统中均被证明是有效的，显示出一些积极的结果。然而，关于这种治疗对各种疾病影响的研究在文献中仍然很少，需要更多精心设计的临床试验来更好地了解 ILIB 在各种全身性疾病中的作用。
