Department of Clinical Oncology, Stem Cells and Cell Therapy, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Lasers Med Sci. 2024 Mar 4;39(1):85. doi: 10.1007/s10103-024-04031-0.
The use of Intravascular Laser Irradiation of Blood (ILIB) as a treatment or adjunct tool has been used around the world since the 1980s. So that more professionals can deliver benefits to their patients in different areas of health, it is necessary to understand in depth the mechanisms of laser action at the molecular level, for correct indication and success in the treatment. To analyze works that evaluated the influence of ILIB on inflammatory cytokines and nitric oxide (NO) in animals and humans. The literature search was carried out between February and April 2023 in Pubmed, Medline, Web of Science, SciELO, Lilacs database. The risk of bias was assessed using the bias table where the authors performed the analyzes of all articles with the risk of bias domains. The methodology was defined following the PRISMA guidelines (Preferred Systematic Reviews and MetaAnalysis Report). The search retrieved 135 possibly relevant articles. After removing duplicates, according to the eligibility criteria, evaluation of titles and review of abstracts, in the end, 6 articles were included. An increase in anti-inflammatory cytokines, a decrease in pro-inflammatory cytokines and an increase in NO can be observed. The wavelengths used ranged from 660 to 808 nm when using a low intensity laser and when using a VIP light source 480-3400 nm, they also differed in terms of the light emission pattern. ILIB may be a complementary treatment option for patients who have comorbidities that lead to systemic inflammation.
自 20 世纪 80 年代以来，血管内激光辐照血液（ILIB）作为一种治疗或辅助工具已在世界各地使用。为了让更多的专业人员能够在不同的健康领域为患者提供益处，有必要深入了解激光在分子水平上的作用机制，以正确地进行治疗。本文分析了评估 ILIB 对动物和人类炎症细胞因子和一氧化氮（NO）影响的研究。文献检索于 2023 年 2 月至 4 月在 Pubmed、Medline、Web of Science、SciELO、Lilacs 数据库中进行。使用偏倚表评估了偏倚风险，作者对所有文章的偏倚域进行了分析。该方法是按照 PRISMA 指南（首选系统评价和荟萃分析报告）定义的。检索到 135 篇可能相关的文章。经过去重后，根据纳入标准，对标题进行评估和摘要进行审查，最终纳入 6 篇文章。结果显示，可观察到抗炎细胞因子增加、促炎细胞因子减少和 NO 增加。使用低强度激光时，使用的波长为 660 至 808nm，而使用 VIP 光源时，波长为 480 至 3400nm，它们在发光模式方面也有所不同。ILIB 可能是合并导致全身炎症的合并症的患者的一种补充治疗选择。
